Zhang S Y, McGaugh J L, Juler R G, Introini-Collison I B
Eur J Pharmacol. 1987 Jun 12;138(1):37-44. doi: 10.1016/0014-2999(87)90334-7.
This study investigated the effect of posttraining administration (i.p.) of naloxone and [Met5]enkephalin on retention in intact and adrenal-denervated mice. Naloxone (0.3 mg/kg) enhanced and [Met5]enkephalin (0.5 or 2.0 micrograms/kg) impaired retention in both inhibitory avoidance and Y-maze discrimination tasks. Further, [Met5]enkephalin antagonized the facilitative effect of naloxone on retention while naloxone attenuated the retention deficit produced by [Met5]enkephalin. However, neither naloxone nor [Met5]enkephalin affected retention in adrenal denervated mice. These findings suggest that endogenous hormones of the adrenal medulla, including [Met5]enkephalin, may be involved in the modulating influence of opiate peptides on memory storage.
本研究调查了训练后腹腔注射纳洛酮和[Met5]脑啡肽对完整小鼠和肾上腺去神经支配小鼠记忆保持的影响。在抑制性回避和Y迷宫辨别任务中，纳洛酮（0.3毫克/千克）增强了记忆保持，而[Met5]脑啡肽（0.5或2.0微克/千克）损害了记忆保持。此外，[Met5]脑啡肽拮抗了纳洛酮对记忆保持的促进作用，而纳洛酮减弱了[Met5]脑啡肽产生的记忆保持缺陷。然而，纳洛酮和[Met5]脑啡肽均未影响肾上腺去神经支配小鼠的记忆保持。这些发现表明，肾上腺髓质的内源性激素，包括[Met5]脑啡肽，可能参与了阿片肽对记忆存储的调节作用。
