Department of Chemistry, Yonsei University, 03722 Seoul, Republic of Korea.
Department of Drug Discovery, Data Convergence Drug Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.
Chem Soc Rev. 2022 Oct 31;51(21):8957-9008. doi: 10.1039/d2cs00722c.
Near-infrared (NIR) fluorophores have unique features that endow them with several advantages over conventional shorter wavelength emitting dyes. As a result, they have been widely utilized as fluorescence and photoacoustic imaging agents, as well as photodynamic and photothermal therapeutic agents. However, non-targeting NIR fluorescence-emitting organic molecules have the drawback of low selectivity toward tumors, which potentially results in severe side effects caused by damage to normal tissues. Thus, the development of NIR fluorophore-based substances that target tumors is a highly active area in medicinal chemistry research. Research efforts carried out thus far have led to the development of a number of NIR fluorophore-based, tumor imaging and therapeutic agents. The discussion in this review focuses on the results of research reported in the 2012-2021 period, giving particular emphasis to studies of NIR small organic dye-based imaging and therapeutic agents that are designed utilizing cancer-selective strategies.
近红外 (NIR) 荧光团具有独特的特性，使它们相对于传统的短波长发射染料具有多个优势。因此，它们已被广泛用作荧光和光声成像剂，以及光动力和光热治疗剂。然而，非靶向 NIR 荧光有机分子对肿瘤的选择性较低，这可能导致正常组织损伤引起的严重副作用。因此，开发针对肿瘤的基于 NIR 荧光团的物质是药物化学研究中的一个活跃领域。迄今为止进行的研究工作导致了许多基于 NIR 荧光团的肿瘤成像和治疗剂的开发。本综述的讨论重点介绍了 2012-2021 年期间报告的研究结果，特别强调了利用癌症选择性策略设计的基于 NIR 小分子有机染料的成像和治疗剂的研究。
