病理性白蛋白尿与亚临床动脉粥样硬化之间的关联存在性别差异：来自宜兰纵向老龄化研究的见解。

Sex difference in the association between pathological albuminuria and subclinical atherosclerosis: insights from the I-Lan longitudinal aging study.

机构信息

Division of Cardiology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Cardiovascular Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.

出版信息

Aging (Albany NY). 2022 Oct 11;14(19):8001-8012. doi: 10.18632/aging.204331.

DOI:10.18632/aging.204331

PMID:36227142

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9596222/

Abstract

BACKGROUND

Pathological albuminuria (PAU) (urinary albumin creatinine ratio [UACR] ≥30 mg/g) is an independent risk factor of cardiovascular disease. PAU is more prevalent in men than women. We aimed to compare the association of PAU and the early phase of subclinical atherosclerosis (SA) between sexes.

METHODS

1228 subjects aged 50-90 years were stratified by sex and UACR (normal or PAU). SA was defined as mean carotid intima-media thickness ≥75th percentile of the cohort. Demographics and SA prevalence were compared between groups. Multivariate logistic regression was performed to assess the relationship between PAU and SA.

RESULTS

Both men and women with PAU had increased prevalence of hypertension, anti-hypertensive therapy, and metabolic syndrome than controls. Men with PAU were older and had greater waist circumference and total body fat percentage. Sex disparity was observed in associations between waist-to-height ratio, total body fat, and UACR. After adjusting for traditional risk factors, multivariate logistic regression disclosed that PAU was independently associated with SA in men (adjusted odds ratio 1.867, 95% CI 1.066-3.210) but not in women.

CONCLUSION

The relationship of PAU and SA differed between sexes. This result may highlight the need for sex-specific risk management strategies to prevent atherosclerosis.

摘要

背景

病理性白蛋白尿（PAU）（尿白蛋白肌酐比值[UACR]≥30mg/g）是心血管疾病的独立危险因素。PAU 在男性中比女性更为常见。我们旨在比较 PAU 和亚临床动脉粥样硬化（SA）早期阶段在性别之间的相关性。

方法

将 1228 名年龄在 50-90 岁的受试者按性别和 UACR（正常或 PAU）分层。SA 定义为颈动脉内膜中层厚度平均值≥队列第 75 百分位数。比较各组之间的人口统计学数据和 SA 的患病率。采用多变量 logistic 回归评估 PAU 与 SA 之间的关系。

结果

PAU 组的男性和女性高血压、抗高血压治疗和代谢综合征的患病率均高于对照组。PAU 组的男性年龄更大，腰围和体脂百分比更高。性别差异表现在腰高比、体脂和 UACR 之间的关联。在调整了传统危险因素后，多变量 logistic 回归显示 PAU 与男性的 SA 独立相关（调整后的优势比 1.867，95%CI 1.066-3.210），但与女性无关。