Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea; Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea.
Biomed Pharmacother. 2022 Dec;156:113764. doi: 10.1016/j.biopha.2022.113764. Epub 2022 Oct 10.
In the liver, reactive oxygen species (ROS) are constantly released during cellular metabolic processes, and excess ROS production can cause redox stress. The redox stress is both beneficial for and harmful to the survival of cells since it modulates the cellular redox control system. The redox control system is a series of cellular responses that are responsible for maintaining a balanced oxidation-reduction status. Many cellular processes including growth, proliferation, and senescence are sensitively regulated by the redox control system. Imbalance of redox induces redox stress and damages DNA, proteins, and lipids in cells, and further contributes to the pathogenesis of severe diseases and disorders like cancer. However, the cellular redox control system also utilizes redox stress-responsive pathways and increases antioxidant enzymes to aid cell survival. Therefore, a deeper understanding of the connection between the redox control system and liver disease is likely to pave the way for the future development of new therapeutic strategies. This review will examine the redox control systems in liver with responsive regulating molecules, current knowledge of the redox control system and liver disease, and suggest potential therapeutic targets for liver diseases.
在肝脏中，细胞代谢过程中会不断产生活性氧（ROS），ROS 过量产生会导致氧化还原应激。氧化还原应激对细胞的生存既有益又有害，因为它调节细胞的氧化还原控制系统。氧化还原控制系统是一系列细胞反应，负责维持氧化还原状态的平衡。许多细胞过程，包括生长、增殖和衰老，都受到氧化还原控制系统的敏感调节。氧化还原失衡会导致氧化还原应激，损害细胞内的 DNA、蛋白质和脂质，进一步导致癌症等严重疾病和疾病的发病机制。然而，细胞氧化还原控制系统也利用氧化还原应激反应途径并增加抗氧化酶来帮助细胞存活。因此，深入了解氧化还原控制系统与肝脏疾病之间的联系，可能为未来开发新的治疗策略铺平道路。本文综述了具有响应调节分子的肝脏氧化还原控制系统、氧化还原控制系统与肝脏疾病的现有知识，并提出了肝脏疾病的潜在治疗靶点。
