Department of Pediatrics MC 0760, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Department of Pediatrics MC 0760, School of Medicine, University of California, La Jolla, San Diego, CA 92093, USA.
Curr Opin Microbiol. 2022 Dec;70:102220. doi: 10.1016/j.mib.2022.102220. Epub 2022 Oct 11.
Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug-discovery pipeline. As more chemically validated targets become available, efforts are shifting to target-based drug discovery. Here, we briefly review some of the most attractive targets that have been identified in recent years.
表型筛选方法已经将众多临床前候选药物纳入抗疟药物发现管道。随着更多经过化学验证的靶点的出现，人们的工作重点正在转向基于靶点的药物发现。在这里，我们简要回顾一下近年来发现的一些最有吸引力的靶点。
