Department of Drug Chemistry and Technology, Sapienza University of Rome, Piazzale A. Moro 5, 00185 Rome, Italy.
Department of Medical Biotechnologies and Translational Medicine, University of Milan, Via Fratelli Cervi 93, 20090 Segrate, Italy.
Nanomedicine. 2022 Nov;46:102611. doi: 10.1016/j.nano.2022.102611. Epub 2022 Oct 10.
Nanoscale echogenic bubbles (NBs), can be used as a theranostic platform for the localized delivery of encapsulated drugs. However, the generation of NBs is challenging, because they have lifetimes as short as milliseconds in solution. The aim of this work has been the optimization of a preparation method for the generation of stable NBs, characterized by measuring: a) acoustic efficiency, b) nano-size, to ensure passive tumour targeting, c) stability during storage and after injection and d) ability to entrap drugs. NBs are monodisperse and ultra-stable, their stability achieved by generation of an amphiphilic multilamellar shell able to efficiently retain the PFC gas. The NBs perform as good acoustic enhancers over a wide frequency range and out of resonant conditions, as tested in both in vitro and in vivo experiments, proving to be a potential platform for the production of versatile carriers to be used in ultrasound-assisted diagnostic, therapeutic and theranostic applications.
纳米级声振气泡（NBs）可用作包裹药物局部递释的治疗平台。然而，NBs 的产生具有挑战性，因为它们在溶液中的寿命只有几毫秒。这项工作的目的是优化一种稳定 NBs 的制备方法，其特征在于测量：a）声效率，b）纳米尺寸，以确保被动靶向肿瘤，c）储存和注射后的稳定性，d）包埋药物的能力。NBs 是单分散的和超稳定的，通过生成能够有效地保留 PFC 气体的两亲性多层壳来实现其稳定性。NBs 在宽频率范围和非谐振条件下都能很好地作为声增强剂，在体外和体内实验中都得到了验证，证明它们是一种多功能载体的潜在平台，可用于超声辅助诊断、治疗和治疗应用。
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