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Effects of anti-GRP gamma-globulin on gastrin release and gastric secretion in the rat: evidence for the physiologic role of endogenous GRP in the regulation of gastric function.

作者信息

Takagi A, Moriga M, Uchino H, Aono M

出版信息

Gastroenterol Jpn. 1987 Jun;22(3):280-4. doi: 10.1007/BF02774253.

DOI:10.1007/BF02774253
PMID:3623010
Abstract

To assess the effects of endogenous GRP on vagal gastrin release and acid secretion, anti-GRP gamma-globulin was infused in anesthetized rats to bind endogenously released GRP. Anti-GRP gamma-globulin blocked the gastrin-releasing effects caused by 4 micrograms/kg/hr of exogenous GRP infusion and suppressed gastrin release by electrical vagal stimulation. In spite of this suppression, anti-GRP gamma-globulin did not alter basal or vagal-stimulated acid secretion.

摘要

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