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泛癌中GNL3L表达、预后及免疫价值的多组学分析

Multi-Omics Analysis of GNL3L Expression, Prognosis, and Immune Value in Pan-Cancer.

作者信息

Liu Pei, Guo Wenjia, Su Ying, Chen Chen, Ma Yuhua, Ma Ping, Chen Cheng, Lv Xiaoyi

机构信息

College of Information Science, Engineering Xinjiang University, Urumqi 830046, China.

College of Software, Xinjiang University, Urumqi 830046, China.

出版信息

Cancers (Basel). 2022 Sep 22;14(19):4595. doi: 10.3390/cancers14194595.

DOI:10.3390/cancers14194595
PMID:36230520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9558978/
Abstract

Guanine nucleotide-binding protein-like 3-like protein (GNL3L) is a novel, evolutionarily conserved, GTP-binding nucleolar protein. This study aimed to investigate the expression, prognosis, and immune value of GNL3L in pan-cancer from multiple omics analyses. Firstly, the expression and prognostic value of GNL3L in pan-cancer were discussed using the TIMER2 database, the GEPIA database, the cBioportal database, COX regression analysis, and enrichment analysis. The association of GNL3L with tumor mutational burden (TMB), tumor microsatellite instability (MSI), mismatch repair (MMR) genes, and immune cells was then analyzed. Finally, an esophageal cancer (ESCA) prediction model was established, and GNL3L clone formation assays were performed. The final results showed that GNL3L is differentially expressed in the vast majority of cancers, is associated with the prognosis of various cancers, and may affect cancer occurrence through processes such as ribonucleoprotein, ribosomal RNA processing, and cell proliferation. At the same time, it was found that the correlation between GNL3L and TMB, MSI, MMR, and various immune cells is significant. The established ESCA prediction model had a strong predictive ability, and GNL3L could significantly affect the proliferation of esophageal cancer cells. In conclusion, GNL3L may serve as an important prognostic biomarker and play an immunomodulatory role in tumors.

摘要

鸟嘌呤核苷酸结合蛋白样3样蛋白（GNL3L）是一种新型的、进化保守的、结合GTP的核仁蛋白。本研究旨在通过多组学分析探讨GNL3L在泛癌中的表达、预后及免疫价值。首先，利用TIMER2数据库、GEPIA数据库、cBioportal数据库、COX回归分析和富集分析，讨论了GNL3L在泛癌中的表达及预后价值。随后分析了GNL3L与肿瘤突变负荷（TMB）、肿瘤微卫星不稳定性（MSI）、错配修复（MMR）基因及免疫细胞的关联。最后，建立了食管癌（ESCA）预测模型，并进行了GNL3L克隆形成实验。最终结果表明，GNL3L在绝大多数癌症中存在差异表达，与多种癌症的预后相关，并可能通过核糖核蛋白、核糖体RNA加工和细胞增殖等过程影响癌症发生。同时，发现GNL3L与TMB、MSI、MMR及多种免疫细胞之间的相关性显著。所建立的ESCA预测模型具有较强的预测能力，且GNL3L可显著影响食管癌细胞的增殖。总之，GNL3L可能作为一种重要的预后生物标志物，并在肿瘤中发挥免疫调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/1111766b78d5/cancers-14-04595-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/4f44b8b432c4/cancers-14-04595-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/2ef012039021/cancers-14-04595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/19277db78f96/cancers-14-04595-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/9ce4b9809b4a/cancers-14-04595-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/1a783f3b517c/cancers-14-04595-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/2c6e6c4b62db/cancers-14-04595-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/3a1b8d08c30c/cancers-14-04595-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/1111766b78d5/cancers-14-04595-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/5b83f2099d4c/cancers-14-04595-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/5591e3465718/cancers-14-04595-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/b4e95f7b4a07/cancers-14-04595-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/df5c1d141736/cancers-14-04595-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/2ef012039021/cancers-14-04595-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/19277db78f96/cancers-14-04595-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/9ce4b9809b4a/cancers-14-04595-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/1a783f3b517c/cancers-14-04595-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/2c6e6c4b62db/cancers-14-04595-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/3a1b8d08c30c/cancers-14-04595-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca0f/9558978/1111766b78d5/cancers-14-04595-g012.jpg

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