组成性异染色质的绿色峡谷：参与细胞分裂控制的蛋白质编码基因。
The Green Valley of Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control.
机构信息
Dipartimento di Biologia e Biotecnologie "Charles Darwin", Sapienza Università di Roma, 00185 Roma, Italy.
Dipartimento di Biologia, Università di Bari, 70125 Bari, Italy.
出版信息
Cells. 2022 Sep 29;11(19):3058. doi: 10.3390/cells11193058.
Constitutive heterochromatin represents a significant fraction of eukaryotic genomes (10% in Arabidopsis, 20% in humans, 30% in , and up to 85% in certain nematodes) and shares similar genetic and molecular properties in animal and plant species. Studies conducted over the last few years on and other organisms led to the discovery of several functions associated with constitutive heterochromatin. This made it possible to revise the concept that this ubiquitous genomic territory is incompatible with gene expression. The aim of this review is to focus the attention on a group of protein-coding genes resident in constitutive of heterochromatin, which are implicated in different steps of cell division.
组成型异染色质代表真核生物基因组的重要部分（拟南芥中占 10%，人类中占 20%， 中占 30%，某些线虫中高达 85%），并且在动物和植物物种中具有相似的遗传和分子特性。过去几年对 和其他生物体的研究发现了与组成型异染色质相关的几种功能。这使得人们有可能修正这样一种概念，即这种普遍存在的基因组区域与基因表达不相容。本文的目的是将注意力集中在一组位于 组成型异染色质中的蛋白编码基因上，这些基因参与细胞分裂的不同步骤。
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