Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Department of Biomedical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St.-Hyacinthe, QC J2S 2M2, Canada.
Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montréal, QC H2X 0A9, Canada.
Int J Mol Sci. 2022 Oct 4;23(19):11780. doi: 10.3390/ijms231911780.
The metrological properties of two performance-based outcome measures of feline osteoarthritis (OA), namely Effort Path (Path) and Stairs Assay Compliance (Stairs), were tested. Cats naturally affected by OA (n = 32) were randomly distributed into four groups (A: 0.40, B: 0.25, C: 0.15, or D: 0.00 mg firocoxib/kg bodyweight) and assessed during baseline, treatment, and recovery periods. For Path, from an elevated walking platform, the cats landed on a pressure-sensitive mattress and jumped up onto a second elevated platform. Analysis included velocity, time to completion, peak vertical force (PVF), and vertical impulse. For Stairs, the number of steps and time to completion were recorded for 16 steps up and down in a 4 min period. Reliability was moderate to very good for Path and poor to good for Stairs. Different normalization methods are described in the manuscript. The placebo group remained stable within-time in Path, whereas treated cats trotted faster on the ramp (p < 0.0001), improved their PVF (p < 0.018) and completed the task quicker (p = 0.003). The percentage of cats completing the Stairs finish line was higher under treatment (p < 0.036), with huge effect size, the placebo group results being stable within-time. Both are promising performance-based outcome measures to better diagnose and manage feline OA pain.
两种猫骨关节炎（OA）基于表现的结果测量方法（Effort Path，Path 和 Stairs Assay Compliance，Stairs）的计量学特性进行了测试。患有 OA 的自然发病猫（n = 32）被随机分为四组（A：0.40、B：0.25、C：0.15 或 D：0.00 mg 非诺考昔/千克体重），并在基线、治疗和恢复期进行评估。对于 Path，猫从升高的行走平台上跳下，落在压力敏感床垫上，然后跳上第二个升高的平台。分析包括速度、完成时间、峰值垂直力（PVF）和垂直冲量。对于 Stairs，在 4 分钟内记录上下 16 步的步数和完成时间。Path 的可靠性为中等至很好，Stairs 的可靠性为差至好。文中描述了不同的归一化方法。安慰剂组在 Path 中保持稳定，而治疗猫在斜坡上跑得更快（p <0.0001），提高了他们的 PVF（p <0.018）并更快地完成任务（p = 0.003）。在治疗下，完成 Stairs 终点线的猫的比例更高（p <0.036），具有巨大的效果量，安慰剂组的结果在时间内保持稳定。这两种方法都是有前途的基于表现的结果测量方法，可更好地诊断和管理猫的 OA 疼痛。
