Sowers J R, Mohanty P K
Hypertension. 1987 Sep;10(3):274-9. doi: 10.1161/01.hyp.10.3.274.
Blood pressure, heart rate, forearm vascular resistance, and hormonal responses to graded lower body negative pressure were investigated in 15 hypertensive men younger than 55 years of age (mean age, 44 +/- 2 years) and 13 comparably hypertensive men older than 55 years of age (mean age, 63 +/- 2 years). Baseline forearm vascular resistance was greater in the elderly group compared with the younger hypertensive men. However, forearm vascular resistance responses to selective unloading of low pressure cardiopulmonary baroreceptors were similar in the two groups. This finding suggests that normal vascular responses to the unloading of cardiopulmonary baroreceptors are preserved in subjects with advancing age and mild to moderate hypertension. Baseline plasma norepinephrine levels, as well as norepinephrine responses to lower body negative pressure, were comparable in the two groups. This finding suggests that, unlike normotensive subjects, essential hypertensive subjects do not have an age-related increase in sympathetic nervous system activity.
对15名年龄小于55岁（平均年龄44±2岁）的高血压男性和13名年龄大于55岁（平均年龄63±2岁）的高血压男性进行了血压、心率、前臂血管阻力以及分级下肢负压时激素反应的研究。老年组的基线前臂血管阻力高于年轻高血压男性。然而，两组对低压心肺压力感受器选择性卸载时的前臂血管阻力反应相似。这一发现表明，在年龄增长和轻至中度高血压患者中，对心肺压力感受器卸载的正常血管反应得以保留。两组的基线血浆去甲肾上腺素水平以及去甲肾上腺素对下肢负压的反应相当。这一发现表明，与血压正常的受试者不同，原发性高血压受试者的交感神经系统活动不会随年龄增长而增加。
