Montgomery S P, Dafny N
Int J Immunopharmacol. 1987;9(4):453-7. doi: 10.1016/0192-0561(87)90019-1.
Cyclophosphamide and cortisol, two nonspecific immunomodulators, significantly reduced the behavioral indices of naloxone-precipitated withdrawal in morphine dependent rats. Each immunomodulator reduced the morphine abstinence syndrome when administered either prior to or after chronic morphine treatment. Morphine exerts numerous effects on all levels of the central nervous system with tolerance, physical dependence, and a withdrawal syndrome being characteristics of this drug class. It is suggested that the degree of opiate dependence is directly correlated with the intensity of the behavioral withdrawal signs. Therefore, success in modifying the abstinence syndrome may lead to a better understanding of the dynamics of opiate dependence. The results reported herein coupled with similar findings for alpha-interferon and cyclosporine, suggest that opiate dependence may involve the immune system.
环磷酰胺和皮质醇这两种非特异性免疫调节剂，可显著降低吗啡依赖大鼠中纳洛酮诱发的戒断行为指标。每种免疫调节剂在慢性吗啡治疗之前或之后给药时，均可减轻吗啡戒断综合征。吗啡对中枢神经系统的各个层面均有多种作用，耐受性、身体依赖性以及戒断综合征是这类药物的特征。有人提出，阿片类药物依赖的程度与行为戒断症状的强度直接相关。因此，成功改变戒断综合征可能有助于更好地理解阿片类药物依赖的动态过程。本文报道的结果，再加上α干扰素和环孢素的类似研究结果，表明阿片类药物依赖可能涉及免疫系统。
