Dafny N, Reyes-Vazquez C
Immunopharmacology. 1985 Feb;9(1):13-7. doi: 10.1016/0162-3109(85)90041-4.
The opiate abstinence syndrome represents a fundamental feature of the addictive process, with the degree of addiction being directly correlated to the intensity of withdrawal. Therefore, the discovery of substances capable of attenuating withdrawal signs may provide insights into the dynamics of opiate addiction. The present study demonstrates that three different types of alpha-interferons modify the behavioral signs associated with naloxone-induced abstinence in rats addicted to morphine. These observations suggest that opiate addiction may, in part, be due to an immune response in that immunomodulators (interferon) are capable of altering the naloxone-induced abstinence syndrome in morphine-dependent rats.
阿片类戒断综合征是成瘾过程的一个基本特征，成瘾程度与戒断强度直接相关。因此，发现能够减轻戒断症状的物质可能有助于深入了解阿片类成瘾的动态过程。本研究表明，三种不同类型的α干扰素可改变吗啡成瘾大鼠中与纳洛酮诱导的戒断相关的行为症状。这些观察结果表明，阿片类成瘾可能部分归因于免疫反应，因为免疫调节剂（干扰素）能够改变吗啡依赖大鼠的纳洛酮诱导的戒断综合征。
