Frija G, Schouman-Claeys E, Bonaly A, Donadieu A M, Heran F, Lacombe P, Bismuth V, Hartl C, Bonnemain B
Invest Radiol. 1987 Jul;22(7):597-602. doi: 10.1097/00004424-198707000-00012.
Arterial enhancement obtained with isotonic contrast media in intravenous digital subtraction angiography was studied. Ten dogs were injected with ioxaglate, iopamidol, and ioxitalamate at equal iodine concentration and at concentrations corresponding to plasma osmolality. Three variables were studied: osmolality, injection rate, and iodine dose. Provided their iodine concentration is sufficient, isotonic contrast media appear as efficient as the corresponding hypertonic formulation, at equal iodine dose. Moreover, the use of isotonic ioxaglate allows a lower dose of iodine to be administered without significant reduction in peak arterial value.
研究了静脉数字减影血管造影术中使用等渗造影剂时的动脉强化情况。给10只狗分别注射了碘克沙醇、碘帕醇和碘他拉酸，注射浓度为相等碘浓度以及与血浆渗透压相当的浓度。研究了三个变量：渗透压、注射速率和碘剂量。在碘剂量相等的情况下，只要碘浓度足够，等渗造影剂似乎与相应的高渗制剂一样有效。此外，使用等渗碘克沙醇时，可以使用较低剂量的碘，而不会显著降低动脉峰值。
