间歇性中枢神经系统照射和鞘内化疗治疗儿童中枢神经系统白血病

Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children.

作者信息

Kim T H, Ramsay N K, Steeves R A, Nesbit M E

出版信息

Int J Radiat Oncol Biol Phys. 1987 Oct;13(10):1451-5. doi: 10.1016/0360-3016(87)90309-9.

Abstract

Between 1979 and 1985, nine children with recurrent CNS leukemia who had previous radiation of more than 1800 cGy to the brain were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIIC). There was no isolated CNS recurrence. Three patients died; one from generalized recurrent disease, two from complications associated with bone marrow transplantation. Six patients are alive without evidence of disease between 9 years and 2 4/12 years from the diagnosis of recurrent CNS leukemia. This experience suggests that IIIC may be an effective treatment for preventing the recurrence of CNS leukemia with minimal side effects.

摘要

1979年至1985年间，对9名复发性中枢神经系统白血病患儿进行了治疗，这些患儿之前脑部接受过超过1800厘戈瑞的放射治疗，采用间歇性中枢神经系统照射和鞘内化疗（IIIC）。没有出现孤立的中枢神经系统复发。3名患者死亡；1名死于广泛性复发性疾病，2名死于与骨髓移植相关的并发症。6名患者存活，自复发性中枢神经系统白血病诊断起9年至2又4/12年期间无疾病证据。这一经验表明，IIIC可能是预防中枢神经系统白血病复发且副作用最小的有效治疗方法。