Becciolini A, Tommasi M S, Porciani S, Fantappiè B, Cellai E, Chiavacci A
Int J Radiat Oncol Biol Phys. 1987 Sep;13(9):1339-42. doi: 10.1016/0360-3016(87)90226-4.
The modifications of serum concentrations of TPA were monitored in patients undergoing curative radiation therapy. Patients with tumors localized in the head and neck were treated with one of four different schedules based on conventional fractionation or multiple daily fractionation where the dose per fraction and total daily dose varied. Serum TPA increased immediately on the first day of irradiation: the higher the dose, the greater the increase. These increases disappeared rapidly after the first few days of treatment. A more limited rise was observed in some cases when treatment was renewed after the first week-end split or after more prolonged interruptions. Results demonstrated that TPA is a valid biochemical marker of acute radiation injury to the salivary tissue.
对接受根治性放射治疗的患者血清组织多肽抗原（TPA）浓度的变化进行了监测。头颈部肿瘤患者根据传统分割或每日多次分割采用四种不同方案之一进行治疗，其中每次分割剂量和每日总剂量各不相同。血清TPA在照射第一天立即升高：剂量越高，升高幅度越大。这些升高在治疗开始后的头几天迅速消失。在第一个周末休息后或更长时间中断后重新开始治疗时，在某些情况下观察到升高幅度更有限。结果表明，TPA是唾液组织急性放射性损伤的有效生化标志物。
