Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616, USA.
Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, Davis, CA 95616, USA.
Physiol Behav. 2022 Dec 1;257:113995. doi: 10.1016/j.physbeh.2022.113995. Epub 2022 Oct 12.
Fibroblast growth factor- 21 (FGF21) is a metabolic stress hormone that is released from the liver in response to various nutritional challenges. Because of its notable effects to improve metabolic health, including body fat loss, glucose control, and hepatosteatosis, several pharmaceutical analogs of FGF21 are in development for the treatment of metabolic disease. In addition, a small but developing literature clearly demonstrates that FGF21 also controls feeding behavior. Pharmacological administration of FGF21 reduces the consumption of simple sugars and other sweet tastants, and it increases the consumption of dietary proteins in males, suggesting another potential mechanism by which FGF21-treatment could improve metabolic health- by promoting healthy eating. Despite that sex is a key biological variable influencing feeding behavior and macronutrient selection, the current literature to date primarily on males. In this study, we investigated the effect of FGF21 on sucrose intake and macronutrient selection in female mice. Similar to our previous findings in male mice, we report that FGF21 administration decreases the consumption of sucrose solution by females, and that this is offset by increased chow intake. Also in agreement with our previous findings in males, we report that FGF21 increases the consumption of dietary protein by female mice, and this is offset by either reduced carbohydrate or by reduced fat intake. Lastly, we find that the effect of FGF21 to direct macronutrient intake in females depends on its actions in neurons. Overall, our data support a role for FGF21 to direct macronutrient intake in a similar manner in female and male mice.
成纤维细胞生长因子 21（FGF21）是一种代谢应激激素，它在肝脏中释放以响应各种营养挑战。由于其改善代谢健康的显著效果，包括体脂减少、葡萄糖控制和肝脂肪变性，几种 FGF21 的药物类似物正在开发中用于治疗代谢疾病。此外，一小部分但不断发展的文献清楚地表明，FGF21 还控制摄食行为。FGF21 的药理学给药减少了简单糖和其他甜味剂的消耗，并增加了雄性的膳食蛋白质消耗，这表明 FGF21 治疗改善代谢健康的另一个潜在机制-通过促进健康饮食。尽管性别是影响摄食行为和宏量营养素选择的关键生物学变量，但目前的文献主要集中在男性上。在这项研究中，我们研究了 FGF21 对雌性小鼠蔗糖摄入和宏量营养素选择的影响。与我们之前在雄性小鼠中的发现相似，我们报告说 FGF21 给药减少了雌性小鼠对蔗糖溶液的消耗，并且通过增加 chow 摄入来抵消这种消耗。同样与我们之前在雄性小鼠中的发现一致，我们报告说 FGF21 增加了雌性小鼠对膳食蛋白质的消耗，并且这通过减少碳水化合物或脂肪摄入来抵消。最后，我们发现 FGF21 引导雌性动物摄入大量营养素的效果取决于其在神经元中的作用。总体而言，我们的数据支持 FGF21 以类似的方式在雌性和雄性小鼠中引导大量营养素摄入的作用。
