Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, No.308 Ningxia Road, Qingdao, 266071, China.
Department of Clinical Laboratory, Zibo Central Hospital, ZiBo, 255000, China.
Virus Genes. 2023 Feb;59(1):1-12. doi: 10.1007/s11262-022-01940-6. Epub 2022 Oct 15.
Epstein-Barr virus (EBV) is a recognized oncogenic virus that is related to the occurrence of lymphoma, nasopharyngeal carcinoma (NPC), and approximately 10% of gastric cancer (GC). EBV is a herpesvirus, and like other herpesviruses, EBV has a biphasic infection mode made up of latent and lytic infections. It has been established that latent infection promotes tumorigenesis in previous research, but in recent years, there has been new evidence that suggests that the lytic infection mode could also promote tumorigenesis. In this review, we mainly discuss the contribution of the EBV lytic phase to tumorigenesis, and graphically illustrate their relationship in detail. In addition, we described the relationship between the lytic cycle of EBV and autophagy. Finally, we also preliminarily explored the influence of the tumorigenesis effect of the EBV lytic phase on the future treatment of EBV-associated tumors.
EB 病毒（EBV）是一种公认的致癌病毒，与淋巴瘤、鼻咽癌（NPC）和大约 10%的胃癌（GC）的发生有关。EBV 是一种疱疹病毒，与其他疱疹病毒一样，EBV 具有由潜伏感染和裂解感染组成的双相感染模式。之前的研究已经证实，潜伏感染促进了肿瘤的发生，但近年来，有新的证据表明裂解感染模式也可能促进肿瘤的发生。在这篇综述中，我们主要讨论 EBV 裂解相在肿瘤发生中的作用，并详细地以图表形式阐明它们之间的关系。此外，我们还描述了 EBV 裂解周期与自噬之间的关系。最后，我们还初步探讨了 EBV 裂解相的肿瘤发生效应对 EBV 相关肿瘤未来治疗的影响。
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