微小RNA介导的爱泼斯坦-巴尔病毒感染调控及其潜在的诊断和治疗意义。

MicroRNA-mediated control of Epstein-Barr virus infection and potential diagnostic and therapeutic implications.

作者信息

Skalsky Rebecca L

机构信息

Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA.

出版信息

Curr Opin Virol. 2022 Oct;56:101272. doi: 10.1016/j.coviro.2022.101272. Epub 2022 Oct 13.

DOI:10.1016/j.coviro.2022.101272

PMID:36242893

Abstract

Herpesviruses, such as Epstein-Barr virus (EBV), encode multiple viral microRNAs that are expressed throughout various infection stages. While much progress has been made in evaluating both the viral and host microRNAs (miRNAs) that are detected during infection as well as elucidating their molecular targets in vitro, our understanding of their contributions to pathogenesis in vivo, viral oncogenesis, and clinical implications for these small molecules remains limited. miRNAs are widely recognized as key regulators of global cellular processes, including apoptosis, cell differentiation, and development of immune responses. This review discusses the roles of miRNAs in EBV infection and current advances in miRNA-based diagnostic and therapeutic strategies potentially applicable toward EBV-associated diseases.

摘要

疱疹病毒，如爱泼斯坦-巴尔病毒（EBV），编码多种病毒微小RNA，这些微小RNA在感染的各个阶段都有表达。虽然在评估感染期间检测到的病毒和宿主微小RNA（miRNA）以及阐明它们在体外的分子靶点方面已经取得了很大进展，但我们对它们在体内发病机制、病毒致癌作用以及这些小分子的临床意义的理解仍然有限。miRNA被广泛认为是全球细胞过程的关键调节因子，包括细胞凋亡、细胞分化和免疫反应的发展。这篇综述讨论了miRNA在EBV感染中的作用以及基于miRNA的诊断和治疗策略在EBV相关疾病中的潜在应用的当前进展。