Hampson Elizabeth
Department of Psychology, University of Western Ontario, London, ON, Canada; Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Front Neuroendocrinol. 2023 Jan;68:101040. doi: 10.1016/j.yfrne.2022.101040. Epub 2022 Oct 13.
Millions of women around the world use combined oral contraceptives (OCs), yet surprisingly little is known about their central nervous system (CNS) effects. This article provides a short overview of the basic pharmacology of OCs, emphasizing features that may be relevant to understanding their effects in the CNS. Historical and recent findings from studies of cognitive function, mood, and negative affect (depressive changes under OC use) are then reviewed. We also present data from an archival dataset from our own laboratory in which we explore dysphoric changes in women using four generations of contraceptive progestins. Current data in the field are consistent with a modest effect of OC use on CNS variables, but conclusions based on current findings must be made very cautiously because of multiple methodological issues in many published studies to date, and inconsistencies in the findings. Directions for future research over the next 10 years are suggested. (150 words).
全球数以百万计的女性使用复方口服避孕药（OCs），然而令人惊讶的是，人们对其对中枢神经系统（CNS）的影响知之甚少。本文简要概述了OCs的基本药理学，重点强调了可能与理解其在CNS中的作用相关的特征。随后回顾了关于认知功能、情绪和负面影响（使用OCs时的抑郁变化）研究的历史和最新发现。我们还展示了来自我们自己实验室存档数据集的数据，在该数据集中我们探讨了使用四代避孕孕激素的女性的烦躁变化。该领域的当前数据与使用OCs对CNS变量有适度影响一致，但由于迄今为止许多已发表研究存在多种方法学问题以及研究结果不一致，基于当前发现得出结论时必须非常谨慎。文中还提出了未来10年的研究方向。 （150字）
