Radhakrishnan Rajiv, Worhunsky Patrick D, Zheng Ming-Qiang, Najafzadeh Soheila, Gallezot Jean-Dominique, Planeta Beata, Henry Shannan, Nabulsi Nabeel, Ranganathan Mohini, Skosnik Patrick D, Pittman Brian, Cyril D'Souza Deepak, Carson Richard E, Huang Yiyun, Potenza Marc N, Matuskey David
Department of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United States.
Department of Psychiatry, Yale University School of Medicinev, New Haven, CT 06511, United States.
Neuroimage. 2022 Dec 1;264:119674. doi: 10.1016/j.neuroimage.2022.119674. Epub 2022 Oct 13.
Brain cannabinoid 1 receptors (CB1Rs) contribute importantly to the regulation of autonomic tone, appetite, mood and cognition. Inconsistent results have been reported from positron emission tomography (PET) studies using different radioligands to examine relationships between age, gender and body mass index (BMI) and CB1R availability in healthy individuals. In this study, we examined these variables in 58 healthy individuals (age range: 18-55 years; 44 male; BMI=27.01±5.56), the largest cohort of subjects studied to date using the CB1R PET ligand [C]OMAR. There was a significant decline in CB1R availability (V) with age in the pallidum, cerebellum and posterior cingulate. Adjusting for BMI, age-related decline in V remained significant in the posterior cingulate among males, and in the cerebellum among women. CB1R availability was higher in women compared to men in the thalamus, pallidum and posterior cingulate. Adjusting for age, CB1R availability negatively correlated with BMI in women but not men. These findings differ from those reported using [C]OMAR and other radioligands such as [F]FMPEP-d and [F]MK-9470. Although reasons for these seemingly divergent findings are unclear, the choice of PET radioligand and range of BMI in the current dataset may contribute to the observed differences. This study highlights the need for cross-validation studies using both [C]OMAR and [F]FMPEP-d within the same cohort of subjects.
脑大麻素1受体（CB1Rs）对自主神经张力、食欲、情绪和认知的调节起着重要作用。正电子发射断层扫描（PET）研究使用不同的放射性配体来检查健康个体的年龄、性别和体重指数（BMI）与CB1R可用性之间的关系，结果并不一致。在本研究中，我们对58名健康个体（年龄范围：18 - 55岁；44名男性；BMI = 27.01±5.56）进行了这些变量的研究，这是迄今为止使用CB1R PET配体[C]OMAR研究的最大样本队列。苍白球、小脑和后扣带回中的CB1R可用性（V）随年龄显著下降。校正BMI后，男性后扣带回和女性小脑中V的年龄相关下降仍然显著。在丘脑、苍白球和后扣带回中，女性的CB1R可用性高于男性。校正年龄后，女性的CB1R可用性与BMI呈负相关，而男性则不然。这些发现与使用[C]OMAR和其他放射性配体如[F]FMPEP - d和[F]MK - 9470所报告的结果不同。虽然这些看似不同的发现的原因尚不清楚，但当前数据集中PET放射性配体的选择和BMI范围可能导致了观察到的差异。本研究强调了在同一队列受试者中使用[C]OMAR和[F]FMPEP - d进行交叉验证研究的必要性。
