Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Viale GB Morgagni 50, Florence 50134, Italy.
Endocrinol Metab Clin North Am. 2022 Dec;51(4):837-852. doi: 10.1016/j.ecl.2022.04.007.
Quality of life is impaired in primary hyperparathyroidism (PHPT), regardless of the severity of the disease. Clinical studies have employed different instruments, including standardized and disease-specific questionnaires, and including patients with different phenotypes of PHPT. Neuropsychiatric symptoms and decline in cognitive status are common in PHPT. Patients may complain of these issues or they can be ascertained by questionnaires; they include depression, anxiety, impaired vitality, social and emotional functions, sleep disturbances, and altered mental function. Randomized controlled trials on the effects of surgical versus non-surgical treatments have collectively shown improvement in quality of life after parathyroidectomy, but results have been heterogeneous.
原发性甲状旁腺功能亢进症（PHPT）会降低生活质量，无论疾病严重程度如何。临床研究采用了不同的工具，包括标准化和特定于疾病的问卷，并纳入了具有不同 PHPT 表型的患者。神经精神症状和认知状态下降在 PHPT 中很常见。患者可能会抱怨这些问题，也可以通过问卷来确定；这些问题包括抑郁、焦虑、活力下降、社会和情感功能受损、睡眠障碍和精神功能改变。关于手术与非手术治疗效果的随机对照试验的综合结果表明，甲状旁腺切除术可改善生活质量，但结果存在异质性。
