Department of Pediatric, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dis Markers. 2022 Oct 4;2022:6133908. doi: 10.1155/2022/6133908. eCollection 2022.
This study was to investigate the characteristics of insulin secretion and the 25-hydroxyvitamin D3 (25(OH)D3) levels in children with obesity.
A retrospective analysis was conducted among children who underwent health checkups in the pediatric healthcare department of our hospital from January 2018 to January 2021, and they were divided into a normal group and an obese group according to their BMI. The insulin secretion and the 25(OH)D3 levels of the two groups of children were compared. A total of 721 children were included in the study, including 591 in the normal group and 130 in the obese group, with an obesity rate of 18.03%.
The blood glucose of the normal group was 4.55 ± 1.75 mmol/L, and the 2 h PG was 7.51 ± 2.11 mmol/L; in the obesity group, they were 6.03 ± 2.16 mmol/L and 8.92 ± 3.24 mmol/L, respectively. The FPG and 2 h PG in the obese group were significantly higher than those in the normal group (all < 0.05). The incidence of IFG/IGT in the normal group was 5.24% (31/591), and the incidence of DM was 3.71% (22/591); the incidence of IFG/IGT in the obese group was 14.62% (19/130), and the incidence of DM was 13.08% (17/130). The incidences of IFG/IGT and DM in the obese group were significantly higher than those in the normal group ( < 0.05). The FINS of the children in the normal group was 18.46 ± 3.15 U/mL, and the HOMA-IR was 2.64 ± 0.62; the above indicators in the obese group were 19.11 ± 4.72 U/mL and 3.01 ± 0.83, respectively. The FINS and HOMA-IR in the obese group were significantly higher than those in the normal group ( < 0.05). The serum 25(OH)D3 level in the normal group was 28.15 ± 5.27 ng/mL, of which 556 cases were normal in 25(OH)D3 and 35 cases were deficient in 25(OH)D3. The serum 25(OH)D3 level in the obese group was 24.35 ± 4.51 ng/mL, of which 112 cases were normal in 25(OH)D3 and 18 cases were deficient in 25(OH)D3. The level of serum 25(OH)D3 in the normal group was significantly higher than that in the normal group, and the ratio of 25(OH)D3 deficiency was significantly lower than that in the normal group ( < 0.05).
The blood glucose level of childhood obesity was significantly increased, the incidence of abnormal glucose metabolism and diabetes was significantly increased, and the level of 25(OH) vitamin D3 was significantly decreased. Lifestyle improvements and vitamin D supplementation play an important role in the prevention of childhood diabetes. Because the major causes of childhood obesity are excessive caloric intake and lack of exercise, the most effective and direct measures to prevent obesity are a reasonable lifestyle, reasonable eating habits, and moderate exercise. Although genetics are critical, there is no reliable way to eliminate obesity genes in the human body. Therefore, the role of obesity genes is required to be ultimately eliminated by reduced caloric intake and increased physical activity.
本研究旨在探讨肥胖儿童的胰岛素分泌特征和 25-羟维生素 D3（25（OH）D3）水平。
对我院儿保科 2018 年 1 月至 2021 年 1 月期间进行健康检查的儿童进行回顾性分析，根据 BMI 将其分为正常组和肥胖组。比较两组儿童的胰岛素分泌和 25（OH）D3 水平。共纳入 721 名儿童，其中正常组 591 名，肥胖组 130 名，肥胖率为 18.03%。
正常组空腹血糖为 4.55±1.75mmol/L，2 小时 PG 为 7.51±2.11mmol/L；肥胖组分别为 6.03±2.16mmol/L 和 8.92±3.24mmol/L。肥胖组 FPG 和 2 小时 PG 均明显高于正常组（均<0.05）。正常组 IFG/IGT 发生率为 5.24%（31/591），DM 发生率为 3.71%（22/591）；肥胖组 IFG/IGT 发生率为 14.62%（19/130），DM 发生率为 13.08%（17/130）。肥胖组 IFG/IGT 和 DM 发生率明显高于正常组（均<0.05）。正常组 FINS 为 18.46±3.15U/mL，HOMA-IR 为 2.64±0.62；肥胖组分别为 19.11±4.72U/mL 和 3.01±0.83。肥胖组 FINS 和 HOMA-IR 均明显高于正常组（均<0.05）。正常组血清 25（OH）D3 水平为 28.15±5.27ng/mL，其中 25（OH）D3 正常 556 例，缺乏 35 例。肥胖组血清 25（OH）D3 水平为 24.35±4.51ng/mL，其中 25（OH）D3 正常 112 例，缺乏 18 例。正常组血清 25（OH）D3 水平明显高于肥胖组，25（OH）D3 缺乏率明显低于肥胖组（均<0.05）。
儿童肥胖的血糖水平明显升高，异常糖代谢和糖尿病的发生率明显升高，25（OH）维生素 D3 水平明显降低。改善生活方式和补充维生素 D 对预防儿童糖尿病具有重要作用。由于儿童肥胖的主要原因是热量摄入过多和缺乏运动，因此预防肥胖最有效和直接的措施是合理的生活方式、良好的饮食习惯和适度的运动。虽然遗传是关键，但目前还没有可靠的方法来消除人体肥胖基因。因此，需要通过减少热量摄入和增加体育活动来消除肥胖基因的作用。
