药物穿过血睾屏障。
Drug transport across the blood-testis barrier.
作者信息
Meng Zhixiang, Liu Yawei, Zhou Jian, Zheng Bo, Lv Jinxing
机构信息
Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated to Soochow University) Suzhou 215124, China.
State Key Laboratory of Reproductive Medicine, Center for Reproduction and Genetics, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University Suzhou 215002, China.
出版信息
Am J Transl Res. 2022 Sep 15;14(9):6412-6423. eCollection 2022.
The blood-testis barrier transfers nutrients to spermatogenic tubules to ensure the normal physiological function of the testes. It also restricts the "entry and exit" of biological macromolecules in the testicular lumen and provides a unique microenvironment for spermatogenesis. This makes the testes a safe place for some viruses and tumors, as immune factors cannot function and drugs fail to reach therapeutic concentrations in the testes. This review aimed to describe the factors regulating the structure and physiological function of the blood-testis barrier. By understanding therapeutic mechanisms of action, drugs can be developed to function in the testicles.
血睾屏障将营养物质转运至生精小管，以确保睾丸的正常生理功能。它还限制生物大分子在睾丸管腔中的“进出”，并为生精过程提供独特的微环境。这使得睾丸成为某些病毒和肿瘤的“安全港”，因为免疫因子无法发挥作用，药物也无法在睾丸中达到治疗浓度。本综述旨在描述调节血睾屏障结构和生理功能的因素。通过了解作用机制，有望开发出能在睾丸中发挥作用的药物。
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