Department of Obstetrics and Gynecology, Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10065, USA.
Institute of Reproductive Medicine, School of Medicine, Nantong University, Nantong, Jiangsu 226001, China.
Trends Pharmacol Sci. 2020 Oct;41(10):690-700. doi: 10.1016/j.tips.2020.07.002. Epub 2020 Aug 10.
Testicular cells produce several biologically active peptides that exert their downstream effects by activating distinct signaling proteins. These biomolecules are now known to support spermatogenesis and effectively enhance paracellular and transcellular diffusion of drugs (e.g., adjudin) across the blood-testis barrier (BTB). We briefly discuss the biomolecules that maintain the BTB: these provide new insights into how the BTB can be modulated to allow therapeutic drugs, including male contraceptives, to be transported across the BTB and more generally across blood-tissue barriers. Information gleaned by studying the BTB, as well as other blood-tissue barriers, augments our understanding of blood-tissue barriers and provides new insights into how drugs can be delivered to organs that are effectively protected by tissue barriers.
睾丸细胞产生几种生物活性肽，通过激活不同的信号蛋白发挥其下游效应。这些生物分子现在被认为可以支持精子发生，并有效地增强药物（如 adjudin）穿过血睾屏障（BTB）的细胞旁和细胞间扩散。我们简要讨论了维持 BTB 的生物分子：这些为了解 BTB 如何被调节以允许治疗药物（包括男性避孕药）穿过 BTB 并更普遍地穿过血液-组织屏障提供了新的见解。通过研究 BTB 以及其他血液-组织屏障获得的信息增加了我们对血液-组织屏障的理解，并提供了关于如何将药物递送到被组织屏障有效保护的器官的新见解。
