西罗莫司诱导的结节性硬化症相关心脏横纹肌瘤消退，该横纹肌瘤导致左心室流出道梗阻。
Sirolimus-Induced Regression of Tuberous Sclerosis-Associated Cardiac Rhabdomyoma Causing Left Ventricular Outflow Tract Obstruction.
作者信息
Winkie Colin, Gelman Jacob, Verhoeven Pieter, Chaudhuri Nita Ray
机构信息
Department of Pediatrics, West Virginia University School of Medicine, West Virginia University Children's, Morgantown, West Virginia.
Department of Pediatrics, Division of Pediatric Cardiology, West Virginia University Medicine Children's, Morgantown, West Virginia.
出版信息
CASE (Phila). 2022 May 20;6(8):361-365. doi: 10.1016/j.case.2022.03.009. eCollection 2022 Oct.
• Cardiac rhabdomyomas are closely associated with tuberous sclerosis. • Obstructive CRs historically have required surgery. • Use of mTOR inhibitors can cause regression and involution of CRs. • Use of mTOR inhibitors can reduce morbidity/mortality associated with cardiac surgery.
• 心脏横纹肌瘤与结节性硬化密切相关。
• 从历史上看，梗阻性心脏横纹肌瘤需要手术治疗。
• 使用雷帕霉素靶蛋白（mTOR）抑制剂可使心脏横纹肌瘤消退和 involution（此处involution 可能有误，推测可能是 involute，意为退化，可翻译为退化）。
• 使用 mTOR 抑制剂可降低与心脏手术相关的发病率/死亡率。
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