Bazmamoun Hassan, Narimani Soheila, Shokouhi Maryam, Esfahani Hossein, Soltanian Ali Reza, Rastgoo Haghi Ali Reza
Department of Pediatric Gastroenterology, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran.
Iran J Pathol. 2022 Summer;17(3):323-327. doi: 10.30699/IJP.2022.546540.2807. Epub 2022 Aug 13.
BACKGROUND & OBJECTIVE: Iron deficiency before birth or in infancy can cause long-term behavioral and neurological disorders. Measuring serum ferritin is an effective way to diagnose iron deficiency but requires significant blood volume from a low birth weight infant. Therefore, the present study was performed to investigate the relationship between serum and urinary ferritin levels in low birth weight infants.
In this cross-sectional study, 76 infants weighing less than 2500 g were studied. To measure serum ferritin level, 1.5 mL of blood and to measure urinary ferritin level, at least 1 mL of urine was collected from each infant. Then the results were compared. Data analysis was performed using SPSS software version 16, and the significance level was considered less than 0.05.
Out of 76 neonates studied, 51.3% were boys, and 80.3% were premature infants. The mean birth weight of infants was 2056.31±318.74 g, and the mean serum and urinary ferritin levels were 134.77±72.35 and 85.55±70.97 ng, respectively. There was a statistically significant relationship between serum and urinary ferritin levels. Also, serum ferritin and urinary ferritin levels had a statistically significant relationship with birth weight and gestational age. The higher the birth weight as well as the age at birth, the higher the serum ferritin and urinary ferritin.
According to the findings of this study, measurement of urinary ferritin level can be used as a noninvasive tool for iron deficiency screening in low birth weight infants instead of serum ferritin level.
出生前或婴儿期缺铁可导致长期行为和神经功能障碍。检测血清铁蛋白是诊断缺铁的有效方法，但需要从低体重婴儿采集大量血液。因此，本研究旨在探讨低体重婴儿血清铁蛋白水平与尿铁蛋白水平之间的关系。
在这项横断面研究中，对76名体重小于2500g的婴儿进行了研究。为检测血清铁蛋白水平，从每名婴儿采集1.5mL血液；为检测尿铁蛋白水平，至少采集1mL尿液。然后对结果进行比较。使用SPSS 16.0软件进行数据分析，显著性水平设定为小于0.05。
在76名研究的新生儿中，51.3%为男性，80.3%为早产儿。婴儿的平均出生体重为2056.31±318.74g，血清铁蛋白和尿铁蛋白的平均水平分别为134.77±72.35和85.55±70.97ng。血清铁蛋白水平与尿铁蛋白水平之间存在统计学显著关系。此外，血清铁蛋白和尿铁蛋白水平与出生体重和胎龄也存在统计学显著关系。出生体重和出生时的年龄越高，血清铁蛋白和尿铁蛋白水平越高。
根据本研究结果，检测尿铁蛋白水平可作为低体重婴儿缺铁筛查的非侵入性工具，替代血清铁蛋白水平检测。
