具有缺铁风险因素的新生儿出生时的铁状态：一项初步研究。
The iron status at birth of neonates with risk factors for developing iron deficiency: a pilot study.
作者信息
MacQueen B C, Christensen R D, Ward D M, Bennett S T, O'Brien E A, Sheffield M J, Baer V L, Snow G L, Weaver Lewis K A, Fleming R E, Kaplan J
机构信息
Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
Women and Newborn's Clinical Program, Intermountain Healthcare, Salt Lake City, UT, USA.
出版信息
J Perinatol. 2017 Apr;37(4):436-440. doi: 10.1038/jp.2016.234. Epub 2016 Dec 15.
OBJECTIVE
Small-for-gestational-age (SGA) neonates, infants of diabetic mothers (IDM) and very-low-birth weight premature neonates (VLBW) are reported to have increased risk for developing iron deficiency and possibly associated neurocognitive delays.
STUDY DESIGN
We conducted a pilot study to assess iron status at birth in at-risk neonates by measuring iron parameters in umbilical cord blood from SGA, IDM, VLBW and comparison neonates.
RESULTS
Six of the 50 infants studied had biochemical evidence of iron deficiency at birth. Laboratory findings consistent with iron deficiency were found in one SGA, one IDM, three VLBW, and one comparison infant. None of the infants had evidence of iron deficiency anemia.
CONCLUSIONS
Evidence of biochemical iron deficiency at birth was found in 17% of screened neonates. Studies are needed to determine whether these infants are at risk for developing iron-limited erythropoiesis, iron deficiency anemia or iron-deficient neurocognitive delay.
目的
据报道，小于胎龄儿（SGA）、糖尿病母亲的婴儿（IDM）和极低出生体重早产儿（VLBW）发生缺铁及可能相关的神经认知发育迟缓的风险增加。
研究设计
我们进行了一项初步研究，通过测量SGA、IDM、VLBW及对照新生儿脐带血中的铁参数，评估高危新生儿出生时的铁状态。
结果
在研究的50名婴儿中，有6名在出生时存在缺铁的生化证据。在1名SGA、1名IDM、3名VLBW和1名对照婴儿中发现了与缺铁一致的实验室检查结果。所有婴儿均无缺铁性贫血的证据。
结论
在17%的筛查新生儿中发现了出生时生化缺铁的证据。需要开展研究以确定这些婴儿是否有发生铁限制红细胞生成、缺铁性贫血或缺铁性神经认知发育迟缓的风险。
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