伴视觉先兆偏头痛的电生理变化评估
Evaluation of electrophysiological changes in migraine with visual aura.
作者信息
Hamurcu Mualla Sahin, Bilen Neslihan Bayraktar
机构信息
Department of Ophthalmology, T.C. Saglik Bakanligi, Ankara Bilkent City Hospital, Ankara, Turkey.
出版信息
Taiwan J Ophthalmol. 2022 Aug 22;12(3):295-300. doi: 10.4103/2211-5056.354281. eCollection 2022 Jul-Sep.
PURPOSE
The purpose of this study was to evaluate the electrical responses in the retina and cortex of migraine patients with electrophysiological tests and compare with healthy controls.
MATERIALS AND METHODS
This prospective study included 18 migraine patients with visual aura and 28 healthy controls. Pattern-reversal visual evoked potentials (VEP) and flash electroretinography (fERG) of migraine patients during the headache-free period were compared with healthy controls.
RESULTS
There were statistically significant differences in VEP results: P100 and N75 amplitudes increased significantly ( = 0.025 and = 0.007 respectively) and P100 latency decreased significantly in migraine patients ( = 0.022). Furthermore, fERG scotopic combined cone and rod amplitude increased significantly in migraine patients ( = 0.01).
CONCLUSION
Migraine brain displays abnormal visual evoked responses in between migraine attacks. In migraine eye, scotopic cone and rod response increased. The results of this study support the hyperexcitability of the retina and cortex in patients with migraine.
目的
本研究旨在通过电生理测试评估偏头痛患者视网膜和皮层的电反应，并与健康对照进行比较。
材料与方法
这项前瞻性研究纳入了18名有视觉先兆的偏头痛患者和28名健康对照。将偏头痛患者在无头痛期的图形翻转视觉诱发电位（VEP）和闪光视网膜电图（fERG）与健康对照进行比较。
结果
VEP结果存在统计学显著差异：偏头痛患者的P100和N75波幅显著增加（分别为P = 0.025和P = 0.007），P100潜伏期显著缩短（P = 0.022）。此外，偏头痛患者的fERG暗视联合视锥和视杆波幅显著增加（P = 0.01）。
结论
偏头痛发作间期大脑显示出异常的视觉诱发反应。在偏头痛患者的眼睛中，暗视视锥和视杆反应增强。本研究结果支持偏头痛患者视网膜和皮层的兴奋性过高。
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