Heinle H, Kling D, Lindner V
Int Angiol. 1987 Jan-Mar;6(1):53-8.
Clinical observations indicate that atherosclerotic vessels are prone to develop vasospasm. It was assumed that this property is related to hypercholesterolemia, but the basic mechanisms are still unknown. To investigate further mechanical stimulation experiments were performed with segments of rabbit carotid arteries. Arteriosclerotic lesions were induced in vivo in these arteries by application of DC impulses either in hyper- or normo- cholesterolemic animals. Contractions were evoked by noradrenaline, KCl or hydrogen peroxide. The results show that all the arteriosclerotic segments were hypersensitive to noradrenaline and hydrogen peroxide, compared with the corresponding controls. An increase in contraction force was also found upon application of KCl to lipid-containing plaques. However, in arteriosclerotic segments obtained from normally fed animals, the contraction response to KCl was lower than in controls. This indicates that complex alterations in the contractile properties occur in smooth muscle during atherogenesis which cannot be explained solely on the basis of the influence of cholesterol on the arterial cells.
临床观察表明，动脉粥样硬化血管易于发生血管痉挛。据推测，这种特性与高胆固醇血症有关，但基本机制仍不清楚。为了进一步研究，我们用兔颈动脉节段进行了机械刺激实验。通过在高胆固醇血症或正常胆固醇血症动物体内施加直流脉冲，在这些动脉中诱发动脉粥样硬化病变。用去甲肾上腺素、氯化钾或过氧化氢诱发收缩。结果表明，与相应的对照相比，所有动脉粥样硬化节段对去甲肾上腺素和过氧化氢都高度敏感。在含脂质斑块上施加氯化钾时，收缩力也增加。然而，在正常饲养动物的动脉粥样硬化节段中，对氯化钾的收缩反应低于对照。这表明在动脉粥样硬化形成过程中，平滑肌的收缩特性发生了复杂的改变，这不能仅仅基于胆固醇对动脉细胞的影响来解释。
