Nano-liposomal encapsulation of phenolics as a potential phytobiotic against infection in mice.

BACKGROUND

contains antibacterial phenolic compounds. The current work was implemented to evaluate the effectiveness of a nanoliposome-encapsulated phenolic-rich fraction (PRF-NLs), as a dietary phytobiotic derived from areal parts, on the inhibition of enteropathogenic () infection in mice.

METHODS

The phenolic-rich fraction was loaded into the nanoliposome structure to obtain a nanometer-scale size liposome with homogenous dispersion. Next, 40 white male balb/c mice were assigned to 4 treatment groups. The PRF-NLs antibacterial potential was evaluated by evaluating the blood parameters, liver lipid peroxidation, and gene expression profiling in the mice challenged by infection.

RESULTS

Mice infected by showed impairment in food intake, weight gain, liver function, ileum morphometric features, and ileum tissue inflammation. The diet of fortified food with the nonencapsulated and nanoliposome-encapsulated phenolic compounds was found to improve these parameters at 10 mg TPC/kg BW/day concentration. Our data indicated that the nanoliposome-encapsulated PRF was more effective in promoting the health parameters in mice as compared to nonencapsulated PRF.

CONCLUSION

It could be concluded that the liposomal encapsulation can promote the solubility, availability, and effectiveness of phenolic compounds playing a key role as phytobiotic in mice intervened by enteropathogenic .