Priyanka Prabhakar, Jayanna Bidarur K, Kiran Kumar Haruvegowda, Divakara Thayamma R, Yathirajan Hemmige S, Glidewell Christopher, Parkin Sean
Department of Chemistry, B. N. M. Institute of Technology, Bengaluru-560 070, India.
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru-570 006, India.
Acta Crystallogr E Crystallogr Commun. 2022 Sep 8;78(Pt 10):984-988. doi: 10.1107/S2056989022008799. eCollection 2022 Oct 1.
The low (90 K) and room (298 K) temperature crystal structures of topiramate azido-sulfate [systematic name 2,3:4,5-bis--(1-methyl-ethyl-idene)-β-d-fructo-pyran-ose azido-sulfate], CHNOS, an inter-mediate in the synthesis of the anti-convulsant drug topiramate, are described. Topiramate azido-sulfate () finds use as a reference impurity standard for topiramate. A modified synthesis and some spectroscopic details are also presented.
描述了抗惊厥药物托吡酯合成中间体托吡酯叠氮硫酸盐[系统名称2,3:4,5-双-(1-甲基-亚乙基)-β-D-果糖吡喃糖叠氮硫酸盐]，CHNOS的低温（90 K）和室温（298 K）晶体结构。托吡酯叠氮硫酸盐（）用作托吡酯的参考杂质标准品。还介绍了一种改进的合成方法和一些光谱细节。
