Kilduff T S, Bowersox S S, Faull K F, Zeller-DeAmicis L, Radeke C M, Ciaranello R D, Heller H C, Barchas J D, Dement W C
J Neurosci. 1987 Sep;7(9):2732-6. doi: 10.1523/JNEUROSCI.07-09-02732.1987.
To evaluate how the activity of a well-established neurotransmitter pathway is modulated by a behavioral state, 3H-spiperone binding sites and dopamine (DA) and DA metabolite concentrations were measured in the striata of ground squirrels in 5 phases of the hibernation cycle. Whereas levels of striatal DA and its deaminated metabolite DOPAC did not change significantly, the concentrations of the O-methylated-deaminated metabolite, homovanillic acid (HVA), decreased in all phases of hibernation relative to euthermia. Striatal 3H-spiperone binding sites declined across the hibernation cycle in parallel with the reduction of HVA concentration; receptor binding affinity was unchanged by arousal state. In conjunction with previously reported findings, these results are consistent with the hypothesis that hibernation is associated with a down-regulation of the postsynaptic D2 receptors secondary to increased extracellular DA concentration and reduced DA degradation.
为了评估一种成熟的神经递质通路的活性如何受到行为状态的调节，在冬眠周期的5个阶段测量了地松鼠纹状体中的3H-螺哌隆结合位点以及多巴胺（DA）和DA代谢物浓度。纹状体中DA及其脱氨基代谢物3,4-二羟基苯乙酸（DOPAC）的水平没有显著变化，而相对于正常体温，在冬眠的所有阶段，O-甲基化脱氨基代谢物高香草酸（HVA）的浓度均降低。纹状体中3H-螺哌隆结合位点在整个冬眠周期中与HVA浓度的降低平行下降；唤醒状态对受体结合亲和力没有影响。结合先前报道的研究结果，这些结果与以下假设一致：冬眠与细胞外DA浓度升高和DA降解减少继发的突触后D2受体下调有关。
