School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Mol Cells. 2022 Oct 31;45(10):673-684. doi: 10.14348/molcells.2022.0092. Epub 2022 Sep 25.
The past two decades have witnessed an upsurge in the appreciation of adipose tissue (AT) as an immuno-metabolic hub harbouring heterogeneous cell populations that collectively fine-tune systemic metabolic homeostasis. Technological advancements, especially single-cell transcriptomics, have offered an unprecedented opportunity for dissecting the sophisticated cellular networks and compositional dynamics underpinning AT remodelling. The "re-discovery" of functional brown adipose tissue dissipating heat energy in human adults has aroused tremendous interest in exploiting the mechanisms underpinning the engagement of AT thermogenesis for combating human obesity. In this review, we aim to summarise and evaluate the use of single-cell transcriptomics that contribute to a better appreciation of the cellular plasticity and intercellular crosstalk in thermogenic AT.
过去二十年见证了人们对脂肪组织（AT）的认识的提高，它作为一个免疫代谢枢纽，拥有异质细胞群体，共同微调全身代谢稳态。技术进步，特别是单细胞转录组学，为剖析支持 AT 重塑的复杂细胞网络和组成动态提供了前所未有的机会。在成年人体内发现具有散热功能的功能性棕色脂肪组织，这极大地激发了人们对利用 AT 产热的机制来对抗人类肥胖的兴趣。在这篇综述中，我们旨在总结和评估单细胞转录组学的应用，以更好地了解产热 AT 的细胞可塑性和细胞间串扰。
