Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Laboratory, Beijing, China.
Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Transl Vis Sci Technol. 2022 Oct 3;11(10):26. doi: 10.1167/tvst.11.10.26.
The purpose of this study was to report the distribution of mean ocular perfusion pressure (MOPP) and its associated factors in Chinese children.
We enrolled 3048 grade 1 students and 2258 grade 7 students of the Anyang Childhood Eye Study in central China. Systolic and diastolic blood pressure (SBP and DBP) were recorded with a digital automatic sphygmomanometer. Intraocular pressure (IOP) was assessed by a non-contact tonometer. MOPP was calculated as 2/3 × (DBP + 1/3[SBP - DBP]) - IOP. Risk factors for myopia were obtained through a questionnaire survey.
The MOPP was 33.83 ± 6.37 mm Hg (mean ± SD) in grade 1, which was lower than 36.99 ± 6.80 mm Hg in grade 7 (P < 0.001). Compared with myopic eyes, non-myopic eyes had higher MOPP in grade 7 (37.72 ± 6.72 mm Hg versus 36.58 ± 6.57 mm Hg, P < 0.001) and in grade 1 (33.88 ± 6.29 mm Hg versus 33.12 ± 7.03 mm Hg, P = 0.12). Multivariable analysis showed that higher MOPP was associated with less myopia (P < 0.001), higher body mass index (BMI; P < 0.001), thinner central corneal thickness (P < 0.001), less time on near work (P < 0.001), and more time on sleeping (P = 0.04).
MOPP was higher in children of older age, with higher BMI, less time on near work, and more time on sleeping, and was higher in eyes with less myopia.
We found that MOPP might be an indicator for the detection of myopia development.
本研究旨在报告中国儿童平均眼灌注压（MOPP）的分布及其相关因素。
我们纳入了中国中部安阳市儿童眼研究的 3048 名 1 年级学生和 2258 名 7 年级学生。使用数字自动血压计记录收缩压和舒张压（SBP 和 DBP）。通过非接触眼压计评估眼压（IOP）。MOPP 计算为 2/3 ×（DBP + 1/3[SBP - DBP]）-IOP。通过问卷调查获得近视的危险因素。
1 年级学生的 MOPP 为 33.83 ± 6.37 mm Hg（平均值 ± SD），低于 7 年级学生的 36.99 ± 6.80 mm Hg（P < 0.001）。与非近视眼相比，7 年级近视眼的 MOPP 更高（37.72 ± 6.72 mm Hg 比 36.58 ± 6.57 mm Hg，P < 0.001），1 年级近视眼的 MOPP 也更高（33.88 ± 6.29 mm Hg 比 33.12 ± 7.03 mm Hg，P = 0.12）。多变量分析表明，较高的 MOPP 与较低的近视程度相关（P < 0.001）、较高的体重指数（BMI；P < 0.001）、较薄的中央角膜厚度（P < 0.001）、较少的近工作时间（P < 0.001）和较多的睡眠时间（P = 0.04）。
年龄较大的儿童、BMI 较高、近工作时间较少、睡眠时间较多的儿童 MOPP 较高，近视程度较低的儿童 MOPP 也较高。
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