Lee B Y, Ostrander L E, Thoden W R, Madden J L
J Rehabil Res Dev. 1987 Summer;24(3):1-8. doi: 10.1682/jrrd.1987.07.0001.
Measurements of local tissue blood flow using a technique of hydrogen clearance were used to examine the effect of lumbar sympathectomy on skeletal muscle blood flow. Polarographic recordings on 25 hydrogen desaturations were obtained with platinized platinum electrodes. Lumbar sympathectomies were done on five canines leaving the contralateral limb as a control. The hydrogen clearance data were modeled with biexponential curves: the initial rapid component and the second slow component yielded a weighted average perfusion through tissue. Average volumetric blood flow in the control limb was 6.08 +/- 0.45 ml/min/100 g tissue while the sympathectomized limb averaged 9.54 +/- 0.61 ml/min/100 g tissue (p less than 0.005). Average blood flow increases ranged from 33 to 83 percent in the sympathectomized limb over the control limb. This significant increase in muscle blood flow following lumbar sympathectomy, if of prolonged duration, may be cause for re-evaluation of the role of sympathectomy in the management of arteriosclerotic occlusive disease.
采用氢清除技术测量局部组织血流，以研究腰交感神经切除术对骨骼肌血流的影响。使用镀铂铂电极记录了25次氢去饱和的极谱图。对5只犬进行腰交感神经切除术，保留对侧肢体作为对照。氢清除数据用双指数曲线建模：初始快速成分和第二个缓慢成分得出组织的加权平均灌注量。对照肢体的平均体积血流量为6.08±0.45毫升/分钟/100克组织，而交感神经切除肢体的平均值为9.54±0.61毫升/分钟/100克组织（p<0.005）。交感神经切除肢体的平均血流增加幅度在对照肢体的33%至83%之间。如果腰交感神经切除术后肌肉血流的这种显著增加持续时间较长，可能需要重新评估交感神经切除术在动脉硬化闭塞性疾病治疗中的作用。
