Department of Cognitive Neuropsychology, Tilburg University, Tilburg, the Netherlands; Leuven Cancer Institute, KU Leuven, 3000 Leuven, Belgium.
Department of Psychology and Behavioural Sciences, Aarhus University, Aarhus, Denmark.
Crit Rev Oncol Hematol. 2022 Dec;180:103859. doi: 10.1016/j.critrevonc.2022.103859. Epub 2022 Oct 17.
Cancer-related cognitive impairment (CRCI) has increasingly been identified over the last two decades in non-CNS system cancer patients. Across Europe, researchers have contributed to this effort by developing preclinical models, exploring underlying mechanisms and assessing cognitive and quality of life changes. The ultimate goal is to develop interventions to treat patients experiencing CRCI. To do so, new challenges need to be addressed requiring the implementation of multidisciplinary research groups. In this consensus paper, we summarize the state of the art in the field of CRCI combined with the future challenges and action plans in Europe. These challenges include data sharing/pooling, standardization of assessments as well as assessing additional biomarkers and neuroimaging investigations, notably through translational studies. We conclude this position paper with specific actions for Europe based on shared scientific expert opinion and stakeholders involved in the Innovative Partnership for Action Against Cancer, with a particular focus on cognitive intervention programs.
在过去的二十年中，人们越来越多地发现非中枢神经系统癌症患者存在与癌症相关的认知障碍（CRCI）。在欧洲，研究人员通过开发临床前模型、探索潜在机制以及评估认知和生活质量变化，为这一努力做出了贡献。最终目标是开发干预措施来治疗患有 CRCI 的患者。为此，需要解决新的挑战，这需要实施多学科研究小组。在这份共识文件中，我们总结了 CRCI 领域的最新技术，结合了欧洲未来的挑战和行动计划。这些挑战包括数据共享/汇集、评估的标准化以及评估额外的生物标志物和神经影像学研究，特别是通过转化研究。我们根据参与抗癌创新伙伴关系的科学专家意见和利益相关者，为欧洲制定了具体的行动方案，特别关注认知干预计划。
