Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, Beijing, 100193, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Science, China Agricultural University, No. 2, West Yuanmingyuan Road, Beijing, 100193, China.
Environ Pollut. 2022 Dec 15;315:120415. doi: 10.1016/j.envpol.2022.120415. Epub 2022 Oct 15.
There is a growing consensus that the appropriate microbiome abundant environment actuates microbiota changes to influence human health. Whether living environment reacts on the threat of contaminants and the underlying mechanism remain largely unknown. Therefore, we constructed microbiome abundant environment models, focusing on their regulatory effects on the obesity induced by the exogenous chemical chlorpyrifos (CPF) and the related mechanisms. The results uncovered that the constructed farm and woodland microbiome abundant environment could protect mice against CPF-induced obesity effectively. The microbiome abundant environment regulated CPF-induced microbiota imbalance, characterized by an increase in Lactobacillus abundance. These altered microbiotas modified the intestinal immune system by increasing the expression of Foxp3 and IL-10, and mitigated intestinal barrier injury by upregulating the expression of IL-22 and intestinal tight junction proteins. Fecal microbiota transplantation could receive similar phenotypes on alleviating CPF-induced obesity development. Our results demonstrate that the microbiome abundant environment attenuates exogenous chemical-induced health risks by remodeling the intestinal microbiota, improving the intestinal ecosystem, and preventing intestinal epithelial leakage.
越来越多的共识认为，丰富的微生物环境会促使微生物群落发生变化，从而影响人类健康。然而，生活环境对外源化学污染物的威胁的反应及其潜在机制在很大程度上仍是未知的。因此，我们构建了丰富微生物环境模型，重点研究其对外源化学污染物毒死蜱（CPF）诱导肥胖的调节作用及其相关机制。结果表明，构建的农田和林地丰富微生物环境可以有效保护小鼠免受 CPF 诱导的肥胖。丰富的微生物环境调节 CPF 诱导的微生物群落失衡，表现为乳杆菌丰度增加。这些改变的微生物群通过增加 Foxp3 和 IL-10 的表达来改变肠道免疫系统，并通过上调 IL-22 和肠道紧密连接蛋白的表达来减轻肠道屏障损伤。粪便微生物群移植可以通过减轻 CPF 诱导的肥胖发展来获得类似的表型。我们的研究结果表明，丰富的微生物环境通过重塑肠道微生物群、改善肠道生态系统和防止肠道上皮渗漏来减轻外源性化学物质引起的健康风险。
