Department of Clinical Biochemistry, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.
Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Kathmandu Univ Med J (KUMJ). 2021;19(76):415-419.
Background COVID-19 has posed a global threat to almost every part of the world. The disease has varied form of presentation and the modern medicine has still not been able to provide definite treatment for the disease. Objective To assess the biochemical parameters in confirmed patients of COVID-19 admitted at B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal. Method This is a retrospective hospital based cross-sectional study conducted in the Department of Biochemistry, B.P. Koirala Institute of Health Sciences, Dharan from October to December, 2020. Convenient sampling technique was used to enroll the data of the patients for whom the biochemical parameters were requested by the clinicians. Routine biochemical tests were performed in Cobas c311 autoanalyzer. Result A total of 202 patients with confirmed COVID-19 infections and admitted at COVID Hospital, BPKIHS were enrolled. The findings depict an elevated liver enzyme (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase and cardiac enzymes (creatine kinase-total and creatine kinase- MB) in the study population. Increased serum ferritin (1026.08±220.53), hs CRP (41.52±5.22) and lactate dehydrogenase 360 [303.50-526.75] was found in the patients. Also, majority of the patients (> 50%) had abnormal biochemical findings. Conclusion Biomarkers like C-reactive protein, lactate dehydrogenase and ferritin have shown significant clinical implications in effective management, monitoring, and assessment of the severity of disease in COVID- 19 patients. Simple and cost-effective markers like CRP, LDH, HbA1c could be used for monitoring the severity of COVID-19 infection.
COVID-19 已对世界几乎每个地区构成全球性威胁。该疾病有多种表现形式，现代医学仍然未能为该疾病提供明确的治疗方法。
评估在尼泊尔 B.P. Koirala 健康科学研究所（BPKIHS）确诊的 COVID-19 患者的生化参数。
这是一项在 2020 年 10 月至 12 月期间在 Dharan 的 BPKIHS 生物化学系进行的回顾性基于医院的横断面研究。采用便利抽样技术招募了临床医生要求进行生化参数检查的患者数据。使用 Cobas c311 自动分析仪进行常规生化测试。
共纳入 202 名确诊 COVID-19 感染并入住 BPKIHS COVID 医院的患者。研究结果显示，研究人群的肝酶（丙氨酸氨基转移酶、天冬氨酸氨基转移酶、碱性磷酸酶、γ-谷氨酰转肽酶和心肌酶（肌酸激酶总酶和肌酸激酶同工酶）升高。患者的血清铁蛋白（1026.08±220.53）、hs CRP（41.52±5.22）和乳酸脱氢酶 360[303.50-526.75]升高。此外，大多数患者（>50%）存在生化异常。
C-反应蛋白、乳酸脱氢酶和铁蛋白等生物标志物在 COVID-19 患者的有效管理、监测和疾病严重程度评估方面具有重要的临床意义。CRP、LDH、HbA1c 等简单且具有成本效益的标志物可用于监测 COVID-19 感染的严重程度。
