159431Department of Otolaryngology, Shaanxi Provincial People's Hospital, Xi'an, China.
74617School of Mechatronic Engineering, Xi'an Technological University, Xi'an, China.
J Biomater Appl. 2023 Jan;37(6):961-968. doi: 10.1177/08853282221132982. Epub 2022 Oct 19.
Conventional treatment for eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is usually limited; consequently, relapses occur frequently, accurate local drug delivery is currently a research area of major interest.
Based on postoperative nasal sinus computed tomography (CT) images, the 3D printing technique was used to design and fabricate a precise track-guided sinus drug delivery device. The control group was treated with glucocorticoids by nasal spray for 1 year according to the conventional method, while the experimental group received topical nasal glucocorticoids using the 3D-printed track-guided precise sinus drug delivery device for 1 year. Scores on the Sino-Nasal Outcome Test (SNOT-22) scale and the Lund-Kennedy nasal endoscopic scale during reexamination at 1 month, 3 months, 6 months, and 1 year after the operation were used as the basis for evaluation.
The follow-up duration was 12 months or more following endoscopic sinus surgery (ESS) with neosinus cavity formation. The two groups showed significant differences in SNOT-22 scores and nasal polyp Lund-Kennedy subscores at 3 months, 6 months, and 1 year (p < 0.001) and no differences in plasma cortisol at 6 months and 1 year (p > 0.05).
Local drug administration using our 3D-printed precise sinus drug delivery device is superior to conventional nasal cavity administration in controlling eCRS recurrence.
嗜酸性慢性鼻-鼻窦炎伴鼻息肉（eCRSwNP）的常规治疗通常效果有限；因此，经常会复发。目前，准确的局部药物输送是一个主要的研究领域。
基于术后鼻窦计算机断层扫描（CT）图像，使用 3D 打印技术设计并制造精确的窦腔药物输送装置。对照组采用常规方法，通过鼻喷糖皮质激素治疗 1 年，实验组采用 3D 打印的窦腔精确药物输送轨道引导器进行 1 年的局部鼻内糖皮质激素治疗。在术后 1 个月、3 个月、6 个月和 1 年复查时，采用 Sino-Nasal Outcome Test（SNOT-22）量表和 Lund-Kennedy 鼻内镜评分作为评估依据。
内镜鼻窦手术（ESS）后随访时间超过 12 个月，窦腔形成。两组患者在术后 3 个月、6 个月和 1 年的 SNOT-22 评分和鼻息肉 Lund-Kennedy 亚评分方面差异有统计学意义（p < 0.001），而在 6 个月和 1 年时的血浆皮质醇差异无统计学意义（p > 0.05）。
与常规鼻腔给药相比，我们的 3D 打印精确窦腔药物输送装置在控制 eCRS 复发方面具有优势。
