Kozanoğlu Ilknur, Kursun Ebru, Demiroglu Yusuf Ziya, Sen Nazan, Kis Cem, Yeşilagaç Hasan, Pocan Gürhan, Gul Eylem, Alıskan Hikmet Eda, Boga Can
From the Department of Physiology Department, Baskent University Medical Faculty, Adana, Turkey.
From the Adana Adult BMT Cente, Baskent University Medical Faculty, Adana, Turkey.
Exp Clin Transplant. 2022 Oct 18. doi: 10.6002/ect.2022.0107.
The adoption of international quality and accreditation standards is important for the success of transplant centers. Guidelines from the Joint Accreditation Committee ISCT-Europe and EBMT (JACIE) have enabled quality management of the operations of clinical units of cellular therapy centers, including cell collection and processing, thus minimizing errors and adverse events. COVID-19 has had significant implications for immunocompromised patients, particularly hematopoietic stem cell transplant recipients, as well as their donors and caregivers. Here, we retrospectively examined measures, taken in our transplant center in Turkey during the pandemic period between March 2020 and October 2021, to investigate how JACIE accreditation has affected patient, donor, product, and employee safety.
We analyzed data on transplant activity, as well as donor, patient, product, and employee safety, during the pandemic in 3 separate 6- month periods. The measures were analyzed starting from March 2020, when the first COVID-19 case was seen in Turkey.
Since the beginning of the pandemic, 140 patients have undergone stem cell transplant in our center. Stem cell transplant was delayed in 22 patients because of the pandemic. Transplant was also postponed due to COVID-19 positivity in 6 patients, and 2 patients died due to COVID-19 infection during the transplant process. Unrelated donor activity continued to be performed safely throughout this period. COVID- 19 infection developed in 12 of the 52 personnel working in the bone marrow transplant unit, one of whom needed intensive care due to severe pneumonia. In terms of quality management activities, the impact of the pandemic was greatest during the first month.
Results from our retrospective study examining the impact of JACIE accreditation in a stem cell transplant center during the COVID-19 pandemic showed that, when national and international guidelines are followed, JACIE accreditation can facilitate adaptation to changing conditions in transplant centers.
采用国际质量和认证标准对移植中心的成功至关重要。国际细胞治疗学会欧洲分会和欧洲血液与骨髓移植协会联合认证委员会（JACIE）的指南已实现对细胞治疗中心临床单位运营的质量管理，包括细胞采集和处理，从而将错误和不良事件降至最低。新型冠状病毒肺炎（COVID-19）对免疫功能低下的患者，尤其是造血干细胞移植受者及其供体和护理人员产生了重大影响。在此，我们回顾性研究了2020年3月至2021年10月大流行期间，我们土耳其移植中心采取的措施，以调查JACIE认证如何影响患者、供体、产品和员工安全。
我们分析了大流行期间3个不同的6个月时间段内的移植活动数据，以及供体、患者、产品和员工安全数据。这些措施从2020年3月开始分析，当时土耳其出现了首例COVID-19病例。
自大流行开始以来，我们中心有140例患者接受了干细胞移植。22例患者因大流行而推迟了干细胞移植。6例患者因COVID-19检测呈阳性而推迟了移植，2例患者在移植过程中因COVID-19感染死亡。在此期间，无关供体活动继续安全进行。在骨髓移植科工作的52名人员中有12人感染了COVID-19，其中1人因严重肺炎需要重症监护。在质量管理活动方面，大流行的影响在第一个月最大。
我们的回顾性研究结果，考察了JACIE认证在COVID-19大流行期间对干细胞移植中心的影响，结果表明，当遵循国家和国际指南时，JACIE认证可以促进移植中心适应不断变化的情况。
