HIV 感染者在深南部的持久病毒抑制：一项观察性研究。
Durable viral suppression among persons with HIV in the deep south: an observational study.
机构信息
Research Operations, Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia.
出版信息
AIDS Care. 2023 Dec;35(12):1836-1843. doi: 10.1080/09540121.2022.2136350. Epub 2022 Oct 19.
This study assessed predictors of stable HIV viral suppression in a racially diverse sample of persons living with HIV (PWH) in the southern US. A total of 700 PWH were recruited from one of four HIV clinics in Metro Atlanta, GA. Data were collected from September 2012 to July 2017, and HIV viral loads were retrieved from EMR for 18 months. The baseline visits and EMR data were used for current analyses. Durable viral suppression was categorized as 1. Remain suppressed, 2. Remain unsuppressed, and 3. Unstable suppression. The number of antiretroviral medications and age were significantly associated with durable viral suppression. Older age, fewer ART medications and availability of social support were positively associated with durable viral suppression over the 18-month observation period. Findings suggest that regimen complexity is potentially a better predictor of viral suppression than self-reported medication adherence. The need for consensus on the definition of durable viral suppression is also urged.
本研究评估了美国南部一组不同种族的 HIV 感染者（PLWH）中 HIV 病毒稳定抑制的预测因素。共有 700 名 PLWH 从佐治亚州亚特兰大市的四个 HIV 诊所之一招募。数据收集自 2012 年 9 月至 2017 年 7 月，从电子病历中检索了 18 个月的 HIV 病毒载量。当前分析使用了基线访视和电子病历数据。持久病毒抑制分为 1. 持续抑制、2. 持续未抑制和 3. 不稳定抑制。抗逆转录病毒药物的数量和年龄与持久病毒抑制显著相关。在 18 个月的观察期内，年龄较大、抗逆转录病毒药物较少和获得社会支持与持久病毒抑制呈正相关。研究结果表明，治疗方案的复杂性可能比自我报告的药物依从性更能预测病毒抑制。也迫切需要就持久病毒抑制的定义达成共识。
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