Abe Y, Saito D, Tani H, Nakatsu T, Kusachi S, Haraoka S, Nagashima H
Jpn Circ J. 1987 May;51(5):535-42. doi: 10.1253/jcj.51.535.
The change in coronary hemodynamics during right or left cardiac sympathetic nerve stimulation was studied in anesthetized open chest dogs. No difference in the increasing rate of mean coronary blood flow between right coronary artery (RCA) and left anterior descending coronary artery (LAD) was observed. However the increasing rate of right ventricular systolic pressure X heart rate (RVSP X HR) was greater than that of left ventricle (LV). With phentolamine injection, cardiac sympathetic nerve stimulation showed similar changes as the controls. Beta-stimulation by isoproterenol infusion did not cause different effects on the increasing rate of coronary blood flow between RCA and LAD. These results showed that cardiac sympathetic nerve stimulation increased the double product of the right ventricle (RV) more than that of the LV and the increase was not affected by phentolamine. Moreover, cardiac sympathetic nerve stimulation, either the right or the left, caused the greater effects on the RV compared to the LV mainly through beta-adrenoceptors, and that the response of the RV to increase in oxygen demand was possibly, in part, different from that of the LV.
在麻醉开胸犬中研究了右侧或左侧心脏交感神经刺激期间冠状动脉血流动力学的变化。未观察到右冠状动脉（RCA）和左冠状动脉前降支（LAD）之间平均冠状动脉血流增加速率的差异。然而，右心室收缩压×心率（RVSP×HR）的增加速率大于左心室（LV）。注射酚妥拉明后，心脏交感神经刺激显示出与对照组相似的变化。通过输注异丙肾上腺素进行β刺激对RCA和LAD之间冠状动脉血流增加速率没有产生不同影响。这些结果表明，心脏交感神经刺激使右心室（RV）的双乘积增加幅度大于左心室，且这种增加不受酚妥拉明影响。此外，右侧或左侧心脏交感神经刺激对右心室的影响大于左心室，主要通过β肾上腺素能受体，并且右心室对氧需求增加的反应可能部分不同于左心室。
