Le Huu Van, Le Cerf Didier
Normandie Univ, UNIROUEN, INSA Rouen, CNRS, PBS UMR 6270, Rouen, 76000, France.
Small. 2022 Dec;18(51):e2204283. doi: 10.1002/smll.202204283. Epub 2022 Oct 19.
Hyaluronic acid (HA) is a naturally occurring polysaccharide which has been extensively exploited in biomedical fields owing to its outstanding biocompatibility. Self-assembly of HA and polycations through electrostatic interactions can generate colloidal polyelectrolyte complexes (PECs), which can offer a wide range of applications while being relatively simple to prepare with rapid and "green" processes. The advantages of colloidal HA-based PECs stem from the combined benefits of nanomedicine, green chemistry, and the inherent properties of HA, namely high biocompatibility, biodegradability, and biological targeting capability. Accordingly, colloidal PECs from HA have received increasing attention in the recent years as high-performance materials for biomedical applications. Considering their potential, this review is aimed to provide a comprehensive understanding of colloidal PECs from HA in complex with polycations, from the most fundamental aspects of the preparation process to their various biomedical applications, notably as nanocarriers for delivering small molecule drugs, nucleic acids, peptides, proteins, and bioimaging agents or the construction of multifunctional platforms.
透明质酸（HA）是一种天然存在的多糖，因其出色的生物相容性而在生物医学领域得到广泛应用。HA与聚阳离子通过静电相互作用进行自组装可生成胶体聚电解质复合物（PEC），这种复合物制备相对简单，采用快速且“绿色”的工艺，同时具有广泛的应用。基于胶体HA的PEC的优势源于纳米医学、绿色化学以及HA固有特性（即高生物相容性、生物可降解性和生物靶向能力）的综合益处。因此，近年来来自HA的胶体PEC作为生物医学应用的高性能材料受到越来越多的关注。鉴于其潜力，本综述旨在全面阐述与聚阳离子复合的来自HA的胶体PEC，从制备过程的最基本方面到其各种生物医学应用，特别是作为递送小分子药物、核酸、肽、蛋白质和生物成像剂的纳米载体或构建多功能平台。
