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基于柔性声透镜的体声波器件用于操控和定向传输微颗粒。

Flexible acoustic lens-based surface acoustic wave device for manipulation and directional transport of micro-particles.

机构信息

Institute of Acoustics, Tongji University, Shanghai 200092, PR China.

School of Electronic and Information Engineering, Tongji University, Shanghai 201804, PR China.

出版信息

Ultrasonics. 2023 Feb;128:106865. doi: 10.1016/j.ultras.2022.106865. Epub 2022 Oct 13.

Abstract

Microfluidics is an emerging technology that is playing increasingly important roles in biomedical and pharmaceutical research and development. Surface acoustic waves (SAWs) have been combined with microfluidics technology to establish a SAW-based microfluidics technology that uses the unique interaction between the two techniques to manipulate substances effectively in fluids on the surface of a substrate. This paper reports a method to generate SAWs using conventional planar ultrasonic transducers and acoustic lenses. Additionally, this method is introduced to manipulate particles effectively on a substrate surface. It is demonstrated that the particle positions can be manipulated precisely in any direction on the substrate surface, thus enabling high-precision particle manipulation. We also proposed the generation of nonplanar SAWs via appropriate design of the acoustic lens and realized directional particle transport. In addition, structures to enhance forward-propagating acoustic beams are proposed. The proposed method has potential for use in microfluidics and biomedical applications, allowing tasks such as flexible cell manipulation on a chip to be performed without complex design or micromachining.

摘要

微流控技术是一种新兴技术,在生物医学和药物研发领域发挥着越来越重要的作用。表面声波(SAW)已经与微流控技术相结合,建立了一种基于 SAW 的微流控技术,利用这两种技术的独特相互作用,有效地在基底表面的流体中操纵物质。本文报告了一种使用传统平面超声换能器和声透镜产生 SAW 的方法。此外,还介绍了一种在基底表面上有效操纵粒子的方法。实验证明,粒子的位置可以在基底表面的任何方向上精确操纵,从而实现高精度的粒子操纵。我们还通过适当设计声透镜来实现非平面 SAW 的产生,并实现了定向的粒子输运。此外,还提出了增强前向传播声束的结构。该方法在微流控和生物医学应用中具有潜在的应用价值,可以实现无需复杂设计或微加工的芯片上灵活的细胞操纵等任务。

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