School of Mechanical Engineering, Shenyang Jianzhu University, Shenyang 110168, China.
School of Sciences, Shenyang Jianzhu University, Shenyang 110168, China.
Soft Matter. 2023 Jun 14;19(23):4166-4187. doi: 10.1039/d3sm00457k.
The introduction of surface acoustic waves (SAWs) into lab-on-a-chip microfluidic systems has contributed to the development of a new cutting-edge technology-SAW-based micro/nano manipulation. Recently, the SAW technology has emerged as an important tool for manipulating micro/nano particles/cell populations by virtue of its simplicity, biocompatibility, non-invasiveness, scalability, and versatility. In custom-designed acoustic fields, this technology can be used to manipulate cells, bacteria, exosomes, and even worms precisely, and it has been used in applications such as biomedical and point-of-care diagnostic systems. In this review paper, we start by providing a comprehensive overview of the fundamental working principle and numerical simulation of SAW-based manipulation. Then, we introduce the recent advancements in the manipulation of organisms based on standing and traveling SAWs, including separation, concentration, and transport. At the end of the review, we discuss the current challenges to and future prospects of SAW-based manipulation. The conclusion is that the SAW technology will open up a new frontier in the microfluidics field and contribute significantly to the development of bioengineering research and applications.
表面声波（SAWs）在微流控芯片系统中的引入推动了一项新兴前沿技术——基于 SAW 的微/纳米操控技术的发展。最近，由于其简单性、生物相容性、非侵入性、可扩展性和多功能性，SAW 技术已成为操控微/纳米颗粒/细胞群体的重要工具。在定制设计的声场中，该技术可用于精确操控细胞、细菌、外泌体，甚至蠕虫，并已应用于生物医学和即时诊断系统等领域。在这篇综述论文中，我们首先全面概述了基于 SAW 的操控的基本工作原理和数值模拟。然后，我们介绍了基于驻波和行波的生物体操控的最新进展，包括分离、浓缩和传输。在综述的最后，我们讨论了基于 SAW 的操控目前面临的挑战和未来展望。结论是，SAW 技术将为微流控领域开辟新的前沿，并为生物工程研究和应用的发展做出重大贡献。
