Sufianov Albert, Begliarzade Sema, Kudriashov Valentin, Nafikova Radmila, Ilyasova Tatiana, Liang Yanchao
Educational and Scientific Institute of Neurosurgery, Рeoples' Friendship University of Russia (RUDN University), Moscow, Russia.
Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Noncoding RNA Res. 2022 Sep 29;8(1):1-7. doi: 10.1016/j.ncrna.2022.09.010. eCollection 2023 Mar.
The development of the vertebrate vascular system is an extremely important and complex process. The circulatory system is the first organ system to develop during embryogenesis. The development of the vasculature into highly branched canals must occur clearly in many places in order to supply oxygen and nutrients to the rapidly developing embryo. This process is mediated by a coordinated response of vascular endothelial and parietal cells to heterogeneous angiogenic signals provided by tissues and organs. MicroRNAs regulate gene expression at the transcriptional and post-transcriptional levels and participate in many important physiological and pathological processes. MicroRNAs mainly play an important role in the developmental regulation of vascular smooth muscle cells and vascular endothelial cells. This article summarizes the research progress of microRNAs in vascular development in recent years, focusing on the regulatory mechanism of miR-126 and miR-17/92 families in vascular endothelial cells, as well as the miR-143/145 family, miR-21 in vascular smooth muscle cell's regulation. The research prospects of the role of microRNAs in vascular development are also presented in this article.
脊椎动物血管系统的发育是一个极其重要且复杂的过程。循环系统是胚胎发生过程中第一个发育的器官系统。为了向快速发育的胚胎供应氧气和营养物质，血管必须在许多部位清晰地发育成高度分支的管道。这个过程是由血管内皮细胞和壁细胞对组织和器官提供的异质血管生成信号的协同反应介导的。微小RNA在转录和转录后水平上调节基因表达，并参与许多重要的生理和病理过程。微小RNA主要在血管平滑肌细胞和血管内皮细胞的发育调控中发挥重要作用。本文综述了近年来微小RNA在血管发育方面的研究进展，重点阐述了miR-126和miR-17/92家族在血管内皮细胞中的调控机制，以及miR-143/145家族、miR-21在血管平滑肌细胞调控中的作用。本文还介绍了微小RNA在血管发育中作用的研究前景。
