Zhao Hanxiao, Li Li, Zhao Ning, Lu Aiping, Lu Cheng, He Xiaojuan
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Cell Dev Biol. 2022 Oct 3;10:1011371. doi: 10.3389/fcell.2022.1011371. eCollection 2022.
Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied with joint destruction. Serious joint destruction will eventually lead to disability and the decline of life quality in RA patients. At present, the therapeutic effect of drugs to alleviate joint destruction in RA is limited. Recently, accumulating evidences have shown that long non-coding RNAs (lncRNAs) play an important role in the pathogenesis of joint diseases. Therefore, this paper reviews the expression change and the action mechanism of lncRNAs in joint destruction of RA in recent years. A more comprehensive understanding of the role of lncRNAs in joint destruction will help the treatment of RA.
类风湿关节炎（RA）是一种伴有关节破坏的全身性自身免疫性疾病。严重的关节破坏最终会导致RA患者残疾和生活质量下降。目前，药物缓解RA关节破坏的治疗效果有限。近年来，越来越多的证据表明，长链非编码RNA（lncRNAs）在关节疾病的发病机制中起重要作用。因此，本文综述了近年来lncRNAs在RA关节破坏中的表达变化及作用机制。更全面地了解lncRNAs在关节破坏中的作用将有助于RA的治疗。
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