Miao Chenggui, Bai Liangliang, Yang Yaru, Huang Jinling
Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.
Anhui Provincial Key Laboratory of Chinese Medicine Compound, Anhui University of Chinese Medicine, Hefei, China.
Front Pharmacol. 2021 Mar 12;12:652751. doi: 10.3389/fphar.2021.652751. eCollection 2021.
Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology, mainly manifested by persistent abnormal proliferation of fibroblast-like synoviocytes (FLSs), inflammation, synovial hyperplasia and cartilage erosion, accompanied by joint swelling and joint destruction. Abnormal expression or function of long noncoding RNAs (lncRNAs) are closely related to human diseases, including cancers, mental diseases, autoimmune diseases and others. The abnormal sequence and spatial structure of lncRNAs, the disorder expression and the abnormal interaction with the binding protein will lead to the change of gene expression in the way of epigenetic modification. Increasing evidence demonstrated that lncRNAs were involved in the activation of FLSs, which played a key role in the pathogenesis of RA. In this review, the research progress of lncRNAs in the pathogenesis of RA was systematically summarized, including the role of lncRNAs in the diagnosis of RA, the regulatory mechanism of lncRNAs in the pathogenesis of RA, and the intervention role of lncRNAs in the treatment of RA. Furthermore, the activated signal pathways, the role of DNA methylation and other mechanism have also been overview in this review.
类风湿关节炎（RA）是一种病因不明的慢性自身免疫性疾病，主要表现为成纤维细胞样滑膜细胞（FLS）持续异常增殖、炎症、滑膜增生和软骨侵蚀，并伴有关节肿胀和关节破坏。长链非编码RNA（lncRNA）的异常表达或功能与人类疾病密切相关，包括癌症、精神疾病、自身免疫性疾病等。lncRNA的异常序列和空间结构、表达紊乱以及与结合蛋白的异常相互作用会通过表观遗传修饰的方式导致基因表达的改变。越来越多的证据表明，lncRNA参与了FLS的激活，而FLS在RA的发病机制中起关键作用。在这篇综述中，系统总结了lncRNA在RA发病机制中的研究进展，包括lncRNA在RA诊断中的作用、lncRNA在RA发病机制中的调控机制以及lncRNA在RA治疗中的干预作用。此外，本综述还概述了激活的信号通路、DNA甲基化的作用等机制。
