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头颈部癌微血管重建术后的加速康复——一项前瞻性研究。

Enhanced recovery after microvascular reconstruction in head and neck cancer - A prospective study.

作者信息

Højvig Jens H, Charabi Birgitte W, Wessel Irene, Jensen Lisa T, Nyberg Jan, Maymann-Holler Nana, Kehlet Henrik, Bonde Christian T

机构信息

Department of Plastic Surgery and Burns Treatment, Copenhagen University Hospital, Rigshospitalet, Copenhagen Denmark.

Department of Otorhinolaryngology, Head and Neck surgery & Audiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

出版信息

JPRAS Open. 2022 Aug 19;34:103-113. doi: 10.1016/j.jpra.2022.08.001. eCollection 2022 Dec.

Abstract

OBJECTIVES

Patients undergoing microvascular reconstruction after head and neck cancer typically have several comorbidities, and the procedures are often followed by complications and prolonged hospitalization. Consequently, the application of (ERAS) for these patients undergoing microvascular reconstruction has gained attention in recent years. ERAS is a peri- and postoperative care concept that has repeatedly shown beneficial results for a wide variety of surgical procedures, including microvascular reconstruction. This study presents the results after the introduction of our ERAS protocol for head and neck cancer reconstruction.

METHODS

We prospectively treated 30 consecutive patients according to our ERAS protocol from June 2019 to December 2020 and compared the results of the treated patients with those of patients treated with our (TRAS) protocol. We are based on our ERAS protocol on the following core elements of recovery: and

RESULTS

The baseline characteristics of the groups were comparable. The ERAS group had a significantly shorter length of stay (13.1 vs. 20.3 days, p < 0.001), significantly shorter time to ambulation (3.0 days vs. 6.4 days, p < 0.001), shorter time to removal of nasogastric tube (13.3 days vs. 22.7 days, p = 0.05), and fewer tracheostomies performed (10% vs. 90%, p < 0.001). There were no differences in complications, flap survival, or 30-day re-admissions between the two groups.

CONCLUSION

The introduction of ERAS in patients with head and neck cancer undergoing microvascular reconstruction seems safe and results in improved recovery.

LEVEL OF EVIDENCE

摘要

目的

头颈部癌症患者在接受微血管重建术后通常伴有多种合并症,术后常出现并发症且住院时间延长。因此,近年来加速康复外科(ERAS)在这些接受微血管重建的患者中的应用受到关注。ERAS是一种围手术期和术后护理理念,已反复证明对包括微血管重建在内的多种外科手术有有益效果。本研究展示了我们对头颈部癌症重建采用ERAS方案后的结果。

方法

2019年6月至2020年12月,我们按照ERAS方案对30例连续患者进行了前瞻性治疗,并将治疗患者的结果与采用我们的传统康复方案(TRAS)治疗的患者结果进行比较。我们的ERAS方案基于以下恢复的核心要素:……

结果

两组的基线特征具有可比性。ERAS组的住院时间显著缩短(13.1天对20.3天,p<0.001),下床活动时间显著缩短(3.0天对6.4天,p<0.001),拔除鼻胃管时间缩短(13.3天对22.7天,p = 0.05),气管切开术实施例数更少(10%对90%,p<0.001)。两组在并发症、皮瓣存活或30天再入院率方面无差异。

结论

对头颈部癌症接受微血管重建的患者引入ERAS似乎是安全的,并能改善恢复情况。

证据级别

3级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee2f/9573822/68e4afaa5303/gr1.jpg

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